: a group of subjects provided a particular treatment in a clinical trial Since this trial did not include a radiation-only treatment arm, it has been questioned whether radiation therapy alone might be as effective as sequential chemotherapy and radiation therapy in preserving the larynx. Everett...
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The “side” on which a patient in a controlled clinical trial is placed, which is usually either a treatment/experimental arm, or a placebo/control (non-treated) arm, assigned in a random fashion. Vox populi (Medspeak) Upper extremity. ...
The hospital remained segregated until the 1950s. But the impacts lasted far longer. Stories of mistreatment at the hospital were passed down through families. When Lockhart attempted to enroll patients in a clinical trial focused on reducing sedation levels in the intensive-care unit, white patient...
In this section, we first briefly describe the design of the clinical trial used for illustration in this case study, in particular regarding PRO data collection. After touching on how missing PRO data were handled, we discuss the various estimands that were illustrated in this case study and ...
The 12-month prevalence of major depressive disorder in nationally representative samples of workers was 6.4% and 2.6% in the US [2] and Japan [3], respectively. Many workers also have depression, anxiety, and psychological distress at the sub-clinical level. For example, there are reports ...
Hybrid control provides comparable treatment-effect estimates with generally improved precision, and thus can be of value to inform early-phase clinical development in metastatic colorectal cancer. Plain language summary Treatment of patients with metastatic colorectal cancer – meaning that it has spread ...
In addition, the experience of working closely with stakeholders in designing and conducting this trial will be useful to researchers seeking to engage with stakeholders in the development and evaluation of complex social service interventions while balancing regulatory, resource, and human subjects ...
A seminal clinical trial involving eight cases and no control subjects found that eight weeks of mindfulness-based cognitive therapy (MBCT) enhanced the well-being and psychological distress of infertile women (IW) [52]. Galhardo et al. [53] allocated IW to the MBP in a controlled clinical ...
Concurrent enrollment, randomization and blinding are tools to ensure comparability of the treatment and the control group and to mitigate bias in the treatment effect estimate. On the other hand control groups, which are observed outside the randomized clinical trial, so called historical controls, ...