altered specificityarginine‐rich motifdisordered proteinfitness landscapeHIV Revneutral evolutionRNA‐protein interactionArginine-rich motifs (ARMs) bind RNA structures with high affinity and specificity, and the human immunodeficiency virus (HIV) exploits ARM-RNA interactions to regulate its lifecycle. The ...
RNA recognition by arginine‐rich peptide motifsRNA recognitionRNA binding proteinsarginine-rich motifA ubiquitious class of RNA‐binding proteins is distinguished by an arginine‐rich motif. Such proteins function in transcription, translation, RNA trafficking, and packaging. Peptide models are derived ...
Arginine can hence be viewed as having a dual nature, capable of forming both π−π and cation−π interactions18,34. It is however not clear from existing studies the extent to which the enhanced LLPS propensity of arginine-rich peptides over lysine-rich peptides arises from the coloca...
2004. Nuclear localiza- tion of the adenovirus E4orf4 protein is mediated through an arginine- rich motif and correlates with cell death. Oncogene 23:7458 -7468. http: //dx.doi.org/10.1038/sj.onc.1207919.Miron, M.J.; Gallouzi, I.E.; Lavoie, J.N.; Branton, P.E. Nuclear ...
The arginine-rich RNA-binding motif of HIV-1 Rev is intrinsically disordered and folds upon RRE binding. Biophys J. 2013; 105:1004-17. [PubMed: 23972852]Casu F, Duggan BM, Hennig M. The arginine-rich RNA-binding motif of HIV-1 Rev is intrinsically disordered and folds upon RRE binding...
The structure of the complex formed by the arginine-rich motif of the transcriptional antitermination protein N of phage λ and boxB RNA was determined by heteronuclear magnetic resonance spectroscopy. A bent α helix in N recognizes primarily the shape and negatively charged surface of the boxB ...
Oligomers of the arginine-rich motif of the HIV-1 TAT protein are capable of transferring plasmid DNA into cells. J Biol Chem 2003; 278(13): 11411-11418.Rudolph C, Plank C, Lausier J, et al. Oligomers of the argininerich motif of the HIV-1 TAT protein are capable of transferring ...
The binding activity of HCV NS3 helicase to the viral RNA was drastically reduced with the mutation at Arg1488 (R1488A) and was also affected by the K1236E substitution in the AX(4)GKS motif and the R1490A and GR1490DT mutations in the arginine-rich motif. Previously, Arg1490 was ...
E. Endosome acidification and receptor trafficking: Bafilomycin A1 slows receptor externalization by a mechanism involving the receptor’s internalization motif. Mol. Biol. Cell 4, 1251–1266 (1993). Article CAS PubMed PubMed Central Google Scholar Kobayashi, T. et al. A lipid associated with ...
An RNautophagy/DNautophagy receptor, LAMP2C, possesses an arginine-rich motif that mediates RNA/DNA-bindingAn RNautophagy/DNautophagy receptor, LAMP2C, possesses an arginine-rich motif that mediates RNA/DNA-bindingdoi:10.1016/j.bbrc.2015.03.025Lysosome...