ARF1-GTP regulates Asriȷ to provide endocytic control of Drosophila blood cell homeostasis [Developmental Biology]Drosophila melanogaster larval hematopoiesis is a well-established model to study mechanisms that regulate hematopoietic niche maintenance and control...
该研究解析了小GTP酶Arf1在卵母细胞成熟过程对减数分裂恢复(G2/M转换)以及纺锤体组装的重要功能。 ADP-核糖基化因子1(Arf1)属于小GTP酶的Ras超家族,在哺乳动物细胞中普遍表达,通过其活性GTP结合和非活性GDP结合构象之间循环发挥作用。先前研究表明,Arf1在有丝分裂过程中参与脂质信号传导和脂质代谢调节介导的非膜泡...
In this process, Arf1 was shown to specifically interact with the coatomer and -COP subunits through its switch I region, and with -COP. Here, we mapped the interaction of the Arf1-GTP switch I region to the trunk domains of and -COP. Site-directed photolabeling at position 167 in the...
(2007). Multiple and stepwise interactions between coatomer and ADP-ribosylation factor-1 (Arf1)-GTP. Traffic 8, 582-593.Sun Z, Anderl F, Frohlich K, Zhao L, Hanke S, Brugger B, Wieland F, Bethune J. Multiple and stepwise interactions between coatomer and ADP-ribosylation factor-1 (Ar...
Membrane curvature induced by Arf1-GTP is essential for vesicle formation. Proc. Natl. Acad. Sci. USA 2008, 105, 11731-11736. [CrossRef] [PubMed]Beck, R. et al. (2008) Membrane curvature induced by Arf1-GTP is essential for vesicle formation. Proc. Natl. Aca...
Arf1-GTP-induced tubule formation suggests a function of Arf family proteins in curvature acquisition at sites of vesicle budding. J. Biol. Chem. 2008, 283, 27717-27723. [CrossRef] [PubMed]Krauss, M., Jia, J.Y., Roux, A., Beck, R., Wieland, F.T., De Camilli, P. and Haucke...
Luo RB, Ahvazi B, Amariei D, Shroder D, Burrola B, Losert W, Randazzo PA. Kinetic analysis of GTP hydrolysis catalysed by the Arf1-GTP-ASAP1 complex. Biochem J. 2007; 402:439-447. [PubMed: 17112341]Luo, R., Ahvazi, B., Amariei, D., Shroder, D., Burrola, B., Losert, W....
(1999). Structural and functional analysis of the ARF1-ARFGAP complex reveals a role for coatomer in GTP hydrolysis. Cell 96, 893-902.J. Goldberg, Structural and functional analysis of the ARF1-ARFGAP complex reveals a role for coatomer in GTP hydrolysis, Cell 96 (1999) 893 - 902....
Arfaptin2 binds preferentially to membrane tubes connected to GUVs when Arf1 is in its active GTP-bound state.Ernesto, E. AmbroggioJames, SillibourneBruno, AntonnyJeanBaptiste, MannevilleBruno, Goud