As a class of anti-microbial peptides, defensins have activity against some bacteria fungi and viruses. The defensins are believed to have molecular conformations stabilized by cysteine bonds, which are essential for biological activity. [0015] The documents U.S. Pat. No. 5,861,378 and U.S...
They often contain a hinge in the middle, due to Gly or Pro residues, which enhances the ability of the peptide to enter the cell (Park et al., 2000). CAPs that form stable β-sheet struc‐ tures contain cysteine residues that are able to form disulphide bonds (usually 1-4 depend‐ ...
for larger structures such as proteins every thermodynamic measurement depends on the length scale of the structure. One reason is that the larger molecule can control up to thousands of waters resulting in collective movements with kcal sums of single-calorie-per-molecule solvent energy changes...
Govil G, Saran A (1972) Molecular orbital calculations on polypeptides and proteins 5. Stable conformations of oxygen-containing peptides. J Chem Soc Faraday Trans 68:1176–1180 ArticleCASGoogle Scholar Yan JF, Momany FA, Hoffmann R, Scheraga HA, McGuire RF (1970) Energy parameters in polypep...
by subjecting the composite structure to a stimulus capable of causing the cross-linking or covalent bonding functionalities of a portion of the molecules making up the composite structure to produce covalent bonds between the molecules of this portion, i.e., to cross-link or stitch together thos...