Peptide bond bioisosteres, such as hydroxyethylamine (Hea), have frequently been used to stabilize metabolically labile peptide bonds in peptidomimetic drug design in an effort to increase the oral bioavailability of drug candidates. However, the impact of the peptide bond bioisosteres on the cell ...
modified side chains that approximate the natural amino acid (10, 11) or by modifying peptide bonds by introducing β-amino acids (12, 13), reducing peptide bonds from the natural amine bonds to aminomethylene (14, 15) or generation of partially modified retro-inverso pseudopeptides (8, 16...
Therefore, pepsin might solubilize the collagen in the skin matrix during the acid-swelling process, by cleaving some peptide bonds, resulting in a higher efficacy in gelatin extraction. The quality of fish gelatin depends on its physicochemical and rheological properties. In addition, the overall ...
Localization and characteristics of transglutaminase in the rabbit and human eyeTransglutaminases (transamidases; endo-γ-gluta-mine: ε-lysine transferases) are calcium-dependent enzymes, which cross-link proteins by introducing covalent ε-(γ-gluta-minyl)lysine pseudopeptide bonds between the ...
The preparation of amides is one of the most common reactions inorganic synthesisand a key reaction for the preparation of peptide drugs and nucleic acid drugs in recent years. The reaction for synthesizing amide bonds is very extensive in the laboratory, and there are currently many...
"UNIQUE PEPTIDE IDENTIFICATION OF RNaseA SUPERFAMILY SEQUENCES BASED ON REINFORCED MERGING ALGORITHMS." Journal of Bioinformatics and Computational Biology 04, no. 01 (February 2006): 75–92. http://dx.doi.org/10.1142/s0219720006001710. Full text Add to bibliography APA, Harvard, Vancouver, ISO...
1). Proteases are mainly involved in the hydrolysis of peptide bonds [23]. All the selected bacterial isolates presented a similar extent of protease production (Additional file 1: Table S1, Fig. 1). HCN produced by rhizobacteria plays a critical role in the biological control of pathogens [...
The ethanol precipitation is a better method to enrich low-molecular-weight metal-peptide fragments (Kong et al., 2021). The addition of alcohols to aqueous solutions decreases the polarity of protein, and favours the hydrogen bonds and α-helical structures, whereas hydrophobic interactions become ...
of the energy term, the function f is a temperature energy function for factors of order higher than two, USCSC is the side-chain - side-chain interaction energy term, USCp is the side-chain peptide group interaction energy term, UppVDW is the peptide group - peptide group van der Waals...
“subunits”), where each subunit may be the same or different. Non-limiting examples of polymers encompassed by the present disclosure include nucleic acids, peptides, and proteins, as well as a variety of hydrocarbon polymers (e.g., polyethylene, polystyrene) and functionalized hydrocarbon ...