mitochondria produce energy for cells by oxidizing substances that are synthesized in the cytosol of the cell, a process known as the citric acid cycle. The fuel that is then produced is in the form called Adenosine Triphosphate (ATP). ATP is considered by scientists to be the energy currency...
p66shc is a protein product of an mRNA isoform of SHC1 gene that has a pro-oxidant and pro-apoptotic activity and is implicated in the aging process. Mitochondria were suggested as a major source of the p66shc-mediated production of reactive oxygen species (ROS), although the underlying me...
Mitochondria Are Dynamically Transferring Between Human Neural Cells and Alexander Disease-Associated GFAP Mutations Impair the Astrocytic TransferData_Sheet_1.pdfdoi:10.3389/fncel.2019.00316Longfei GaoZhen ZhangJing LuGang Pei
Here, we review the role of mitochondria in cellular senescence, particularly the impact of mechanisms regulating mitochondrial homeostasis, mitochondrial metabolites and ROS generation in the signalling pathways responsible for the induction and maintenance of cellular senescence. 2. The role of ...
Damaged mitochondria are removed by autophagy. Therefore, impairment of autophagy induces the accumulation of damaged mitochondria and mitochondrial dysfunction in most mammalian cells. Here, we investigated mitochondrial function and the expression of mitochondrial complexes in autophagy-related 7 (Atg7)-defi...
Diabetes increases the risk of Alzheimer’s disease (AD), and mitochondrial dysfunction is implicated in both diseases, however the impact of both diabetes and AD on brain mitochondria is not known. We measured mitochondrial DNA (mtDNA), an indicator of mitochondrial function, in frontal, parietal...
In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability. Mol. Cell 6, 683–692 (2000). CAS PubMed Google Scholar Weinberg, S.E., Sena, L.A. & Chandel, N.S. Mitochondria in the regulation of innate and adaptive...
Cells without mitochondria are more tolerant to an anaerobic environment but are essentially irreversibly committed to death. Prevention of mitochondrial loss may be crucial for the long-term regeneration of tissues emerging from an apoptotic episode in which death was prevented by caspase blockade....
Recent evidence indicates that mitochondria lie at the heart of immunity. Mitochondrial DNA acts as a danger-associated molecular pattern (DAMP), and the mitochondrial outer membrane is a platform for signaling molecules such as MAVS in RIG-I signaling, and for the NLRP3 inflammasome. Mitochondrial...
Mitochondria‐targeted GFP highlights the heterogeneity of mitochondrial shape, size and movement within living plant cells Little is known concerning the heterogeneity of mitochondrial shape, size, number, cytoplasmic distribution, and motility in planta. Ultrastructural studie... DC Logan,CJ Leaver - 《...