In this respect, B-cells and macrophages provide additional possibilities that may be explored for immunotherapy. Here we consider the current state-of-the-art of immunotherapy strategies for OC treatment and evaluate their potential for future improvements....
In the present study, we investigated in vivo the infection and APC functions of dendritic cells (DC) and macrophages (Mφ) after administration of live mycobacteria to mice. Experiments were conducted with Mycobacterium bovis bacillus Calmette-Guerin (BCG) or a rBCG expressing a reporter Ag. Fol...
Cross-presentation: dendritic cells and macrophages bite off more than they can chew! As immunologists, our knowledge of the molecular mechanisms which underlie the presentation of antigens derived from extracellular or 'exogenous' sources t... S Brode,PA Macary - 《Insect Science》 被引量: 128...
Increasing evidence points to dysfunction of the innate immune system including activation of microglia and perivascular macrophages, increases in inflammatory cytokines/chemokines in brain tissue and CSF, and abnormal peripheral monocyte cell function. Dendritic cells are major players in innate immunity ...
We also observed MVA infection of macrophages and B cells, although to a lesser degree comparing to DCs. It remains unclear whether these cells can also present viral Ags and activate T cells in vivo following MVA infection. Using the CD11c-DTR mouse model that allows the conditional ablation ...
Estrogen Receptor {alpha} (ER{alpha}) Deficiency in Macrophages Results in Increased Stimulation of CD4+ T Cells while 17{beta}-Estradiol Acts through ER{a... The effects of 17beta-estradiol (E(2)) on immune function have been extensively reported. The effects are dependent on concentration ...
Galectin-9 prolongs the survival of septic mice by expanding tim-3-expressing natural killer T cells and PDCA-1 + CD11c + macrophages cells.Galectin-9 exhibited a protective effect in polymicrobial sepsis as demonstrated in galetin-9 transgenic mice and therapeutic galectin-9 administration. ... ...
CD206 or CD11c diphtheria toxin receptor transgenic (DTR) mice, which enable depletion of CD206+ M2 Ms and CD11c+ M or CD11c+ Dendritic cells (DCs), respectively, were used. Oocytes were used for in vitro fertilization and embryo transfer. In vitro fertilized embryos derived from M2 M ...
Macrophages (Ms) are involved in folliculogenesis and ovulation. However, it is unknown which type of M, M1 or M2, plays a more essential role in the ovary. CD206 or CD11c diphtheria toxin receptor transgenic (DTR) mice, which enable depletion of CD206+ M2 Ms and CD11c+ M or CD11c+ ...
Dendritic cells (DCs), monocytes, and macrophages are leukocytes with critical roles in immunity and tolerance. The DC network is evolutionarily conserved; the homologs of human tissue CD141hiXCR1+CLEC9A+ DCs and CD1c+ DCs are murine CD103+ DCs and CD64−CD11b+ DCs. In addition, human ...