Storage of Reconstituted ProteinShort-term storage: Store at 2-8°C for (1-2 weeks). Long-term storage: Aliquot and store at -20°C to -80°C for up to 3 months, reconstitution with sterile water and addition of an equal volume of glycerol. Avoid repeat freeze-thaw cycles. ...
Developmental biology Deciphering ARAP3 functions in hematopoiesis and hematopoietic stem cells UNIVERSITY OF PENNSYLVANIA Wei Tong SongYiwenARAP3 is a GTPase-activating protein that inactivates Arf6 and RhoA GTPases. ARAP3 deficiency in mice causes a sprouting angiogenic defect resulting in embryonic ...
Sterile alpha motif (Sam) domains are small protein modules that can be involved in homotypic or heterotypic associations and exhibit different functions. Previous studies have demonstrated that the Sam domain of the lipid phosphatase Ship2 can hetero-di
Keywords: ARAP3 protein; nerve growth factor; neu- rites; p190RhoGAP; PC12 cells; Rap1; RhoA Introduction Nerve growth factor (NGF) is best known as a molecule that promotes the survival and differen- tiation of sensory and sympathetic neurons. Studies on the intracellular signaling cascades ...
et al. Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC. Curr. Biol. 8, 1195–1198 (1998). Article CAS PubMed Google Scholar Stambolic, V. et al. Negative regulation of PKB/Akt-dependent cell survival by the ...
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Synonyms ARF-GAP, RHO-GAP, ankyrin repeat, and plekstrin homology domains containing protein 3 ; Centaurin delta 3 ; Centd3 ; Drag1 ; Expressed sequence AI851258 . Historical Background Small GTPases of the Ras superfamily are binary switches that, by cycling between active GTP-bound and ...
ENDOTHELIAL cellsGTPASE-activating proteinLEAKAGENEUTROPHILSBLOOD proteinsCADHERINSVascular permeability is temporarily heightened during inflammation, but excessive inflammation-associated microvascular leakage can be detrimental, as evidenced in the inflamed lung. Formylated peptides regulate vascular leakage ...
ARAP3ARF-GAP, RHO-GAP, ankyrin repeat, and pleckstrin homology domains containing protein 3; Centaurin delta 3; Centd3; Drag1; Expressed sequence AI851258 Small GTPases of the Ras superfamily are...doi:10.1007/978-3-319-67199-4_611Sian-Eleri Owens...
protein(GAP)RashomologgeneARAP3 (Arf-GAP with Rho-GAP domain, ANK repeat, and PH domain-containing protein 3) is unique for its dual specificity GAPs (GTPase-activating protein) activity for Arf6 (ADP-ribosylation factor 6) and RhoA (Ras homolog gene family member A) regulated by ...