作者研究了27c可能与MDM2相互作用并通过泛素-蛋白酶体系统降解AR/AR-V7的降解机制,并有效抑制AR/AR-V7.核转位和AR信号通路相关基因的表达。27c对22RV1细胞的ER和MR没有降解作用,表明27c对核受体具有良好的选择性。此外,27c在...
优选化合物27c能结合AR-NTD区,并选择性降解AR/AR-V7,而不影响核受体ER、MR;且在AR-V7阳性细胞系22RV1和移植瘤中均表现出优于恩杂鲁胺的抗肿瘤效果。本研究为靶向AR-V7的药物研发提供了新的思路和策略。 示意图 此外,该团队...
MRHI Dodda,KRHI Pingili 摘要: Process for the production of crystalline linezolide form III, characterized by an X-ray bending spectrum with peaks, expressed as 2h at approximately 7.6, 9.6, 13.6, 14.9, 18.2, 18.9, 21.2, 22.3, 25.6, 26.9, 27.9 and 29.9 degrees (a) acetylation of (S)...
Chemistry is beautiful. What if the Moon was a pixel in size? Designer Josh Worth gives us ascale tour of the Solar System. One of my favorite quotes from the presentation is this one: Emptiness is actually everywhere. It’s something like 99.9999999999999999999958% of the known universe. ...
2024-06-04 QCDGE database, Quantum Chemistry Database with Ground- and Excited-state Properties of 450 Kilo Molecules Yifei Zhu et.al. 2406.02341 null 2024-06-04 Kilonova Seekers : the GOTO project for real-time citizen science in time-domain astrophysics T. L. Killestein et.al. 2406.02334...
chemistrymadman / AR.js chenlin9032 / AR.js chenpaopao / AR.js-1 chenyu116 / AR.js cheroguzman / AR.js Chestermozhao / AR.js chethansai / AR.js-1 chipohao / AR.js ChoiMinSik-Kyle / AR.js chowing110 / AR.js chris-warner / AR.js ...
Lineage plasticity of prostate cancer is associated with resistance to androgen receptor (AR) pathway inhibition (ARPI) and supported by a reactive tumor microenvironment. Here we show that changes in chondroitin sulfate (CS), a major glycosaminoglycan c
In: Rosen MR, Janse MJ, Wit AL (eds) Cardiac electrophysiology: a textbook. Futura, Mount Kisco, NY, pp 491–516 Fish JM, Antzelevitch C (2004) Role of sodium and calcium channel block in unmasking the Brugada syndrome. Heart Rhythm 1(2):210–217 Liu DW, Gintant GA, Antze...
Chemistry in Cultural HeritageAI and the Future of Cultural HeritageAI Innovation in Cultural Heritage Preservation: Bridging Technology, Image, and TraditionAnalytical Chemistry for Archaeology and Cultural HeritageAncient Glass under the Magnifying Glass: Electron and Light Microscope InvestigationsAncient ...
Ligand-centred chemistry of molybdenum organoimides. Formation of C–C bonds via generation of nitrogen ylides, stereospecific conversion of an allylimide ... The range of imides trans-[MoCl(NCHR1R2)(dppe)2]+ made from the nitride trans-[MoCl(N)(dppe)2](dppe ... Shirley,A.,Fairhurst,....