作者研究了27c可能与MDM2相互作用并通过泛素-蛋白酶体系统降解AR/AR-V7的降解机制,并有效抑制AR/AR-V7.核转位和AR信号通路相关基因的表达。27c对22RV1细胞的ER和MR没有降解作用,表明27c对核受体具有良好的选择性。此外,27c在...
优选化合物27c能结合AR-NTD区,并选择性降解AR/AR-V7,而不影响核受体ER、MR;且在AR-V7阳性细胞系22RV1和移植瘤中均表现出优于恩杂鲁胺的抗肿瘤效果。本研究为靶向AR-V7的药物研发提供了新的思路和策略。 示意图 此外,该团队...
distributed throughout the genome1. Depending on the molecular context and the localization of the AREs, AR can act as a transcriptional enhancer or repressor2,3.
Although everyone thought he would be a distraction during the battle, he made the greatest difference of all by saving 75 lives of other soldiers empty-handed. In terms of acting, the cast as a whole is incredible with Andrew Garfield, Hugo Weaving, Vince Vaughn, Luke Bracey and Teresa ...
Giving students the chance to actively participate with their subject matter puts fun and wonder back into learning. Virtual reality is unique because it encourages immersive exploration, which can make a huge difference for long-term retention. Instead of feeling bored, sitting behind a desk, stude...
The man would then put it on his bike and go off down the hill with it. Although Peter was always __8__ to find gold or other valuable things __9__ in the straw, he never found __10__. He was sure the man was __11__ something, but he was not __12__ to think out ...
2020-04-20 Learning What Makes a Difference from Counterfactual Examples and Gradient Supervision Abstract | PDF 2020-04-18 CausalVAE: Disentangled Representation Learning via Neural Structural Causal Models Abstract | PDF 2020-04-17 Unsupervised Discovery of Implicit Gender Bias Abstract | PDF 202...
Folders and files Latest commit Cannot retrieve latest commit at this time. History924 Commits .github/workflows update: cron time Dec 21, 2022 docs Github Action Automatic Update CV Arxiv Papers Feb 7, 2023 .gitignore add wechat.md Jan 16, 2022 README.md Github Action Automatic Update CV...
THERMAL DEGRADATION CHEMISTRY OF ARCHAEOLOGICAL PINE PITCH: ALONE AND MIXED WITH BEESWAX[1] Colombini M. P.,Giachi G., Modugno F., Pallecchi P., Ribechini E., 2003.The characterization of paints and waterproofing materials from the shipwrecks found at the archaeological site of the Etrusca...
Thanks to scripts by Friz Freleng’s storyman Warren Foster in it’s second season and the endearing characters of Huck, Yogi and Boo Boo, and Pixie, Dixie, and Mr. Jinks, there was plenty to love about the show, despite the limited animation. Even that had it’s charms, due to ex...