The initial AFB1-N7-Gua adduct, AFB1–FAPY, and the apurinic (AP) site, individually or collectively, represent the likely chemical precursors responsible for the genotoxic effects of AFB1 [30,31]. AP sites, whether chemically induced or generated by glycosylases, are repaired by BER (reviewe...
The apurinic sites are removed by excision repair and deoxycytidyltransferase can include deoxycytidine across the apurinic site and DNA polymerase 味 makes further repair. glycosylases , abasic sites , depurination , excision repair ; Lindahl T, Nyberg B 1972 Biochemistry 11:3610; Haracska L ...
[主观题] AP位点(apurinic site) AP位点(apurinic site) 查看答案更多“AP位点(apurinic site)”相关的问题 第1题 群时延定义为系统相频特性的微分。() 群时延定义为系统相频特性的微分。() 点击查看答案 第2题 设 试用定义证明f(x,y)在点(0,0)可微分 设试用定义证明f(x,y)在点(0,0)可微分...
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Figure 2.Branching pathways of BER. The topmost branch depends on the type of AP site incision: AP endonuclease (left) vs. AP lyase (right; the lyase Schiff base intermediate is shown). LP-BER flows down the left, and single-nucleotide BER on the right. See text for details. RFC, t...
Solution structures of the two PBZ domains from human APLF and their interaction with poly(ADP-ribose).HumansDNA-(Apurinic or Apyrimidinic Site) Lyase... S Eustermann,C Brockmann,PV Mehrotra,... - 《Nature Structural & Molecular Biology》 被引量: 300 X-ray repair cross-complementing gene...
Processing in vitro of an abasic site reacted with methoxyamine: a new assay for the detection of abasic sites formed in vivo. In this study we demonstrate that the different substrate recognition properties of bacterial and human AP endonucleases might be used to quantify and loca... S Rosa...
7A). We also used the published MCM5 site downstream of HMOX-1 as a negative control for nonspecific chromatin binding. PaCa-2 were treated with E3330, RN7–58, vehicle control (Fig. 7, B and C), or Ref-1 siRNA#1, Ref-1 pooled siRNA #2 and #3, or scrambled control (Fig. 7...
This study presents an innovative method for the highly sensitive detection of apurinic/apyrimidinic endonuclease 1 (APE1), a crucial biomarker and target for cancer diagnosis and treatment. The method is predicated on our discovery that the apurinic or apyrimidinic site (AP site) can inhibit ...
APE1 can also cleave at AP-site-containing single-stranded RNA [3], [32]. Since APE1 has 3′–5′ DNA exonuclease activity [18], [19], [20], [21], as well as the ability to remove a phosphoryl group from the 3′ end of DNA [10], [17], we were interested in determining ...