As a molecular imaging agent, nanoparticles (NPs) enhance the specificity of tumor cells, stability in vitro and in vivo, and prolong the circulating half-life [24]. Nanomaterials have a variety of therapeutic functions due to their various characteristics, and have broad application prospects in ...
Aptamers can be selected for any molecules, virus particles, bacteria, cells, and tissues. They have a wide range of applications from target identification to drug delivery. Aptamers themselves can affect various cell functions by affecting certain proteins and receptors. Here, we present the ...
Aptamers can be selected for any molecules, virus particles, bacteria, cells, and tissues. They have a wide range of applications from target identification to drug delivery. Aptamers themselves can affect various cell functions by affecting certain proteins and receptors. Here, we present the ...
and thus interfere with their cellular functions (Hoppe-Seyler et al 2004,Baines & Colas 2006). Peptide aptamers were initially used to inactivate specific proteinsin vivoin order to determine their functions (Colas et al 1996). Soon it was realized that that this strategy has applications in ...
They show high flexibility and stability, are cheap to produce, and easy to modify. These are interesting properties for real sample applications. Aptamers can be developed by in vitro screening of the various types of targets, ranging from small molecules to whole cells, thus making it possible...
In recent years, MNFs have gradually gained momentum in the field of cancer treatment by combining the catalytic functions of metal ions with the therapeutic functions of nucleic acid drugs7,8,9,10. MNFs are composed of metal ions and DNA sequences, resembling another famous material “Metal-...
Unfortunately, their performance was limited by the motifs’ intrinsic pH-responses and could not be tuned to operate across arbitrary pH ranges. Here, we present a methodology for converting virtually any aptamer into a molecular switch with pH-selective binding properties — in acidic, neutral, ...
Recently, aptamer-based drug delivery systems (DDSs) emerged as attractive platforms for precise medicine by targeting to disease cells and reducing the side effects. Aptamers are single-stranded RNA or DNA with high binding affinity and specificity agai
Moreover, the unique spectro- scopic and thermotherapeutic properties of nanomaterials provide superior advantages for sensing, imaging and therapeutic applications. As shown in Figure 1, biomolecule– nanomaterial hybrids are readily applicable to many areas. In particular, accurate diagnosis and effective...
Small molecules such as neurotransmitters are critical for biochemical functions in living systems. While conventional ultraviolet–visible spectroscopy and mass spectrometry lack portability and are unsuitable for time-resolved measurements in situ, techniques such as amperometry and traditional field-effect ...