(https://www.guidetopharmacology.org/), an informative go-to site to clarify the pharmacological mechanism of action of molecules based on indexed literature. The entire list of novel drugs approved in 2023 can be found in TableS1. Drugs that belong to different categories, such as small ...
Table 1 Newly approved drugs grouped by novelty. For definitions, see Introduction. Percentages are those of first-in-indication, first-in-class, and next-in-class drugs with all drugs (included cellular and gene therapies) approved in 2023 taken as 100%. Where available, the International Nonp...
There is great interest in drugs that are capable of modulating multiple aging pathways, thereby delaying the onset and progression of aging. Effective str
The suffix 'meran' is used for mRNA vaccines, just as 'caine' is the suffix for local anesthetics and 'ast' is for anti-asthma drugs.后缀meran 指代的是mRNA疫苗，类似的还有，地方麻醉药名会用caine作为后缀，而ast是抗哮喘药物名的后缀。The Brand Institute began working on names for the vaccine...
Buy, Sell, Hold: mRNA - Part 2 Buy, Sell, Hold: mRNA - Part 1 Behind the Headlines: 2025 Wish List The Challenges, Successes, and Future of Bispecific Antibodies Exploring Automation in Analytical Technologies that Facilitate Process Development Cell Culture Optimization—Part Two Cell Culture Opt...
23 SMN2 exon 7 carries a single nucleotide change with respect to SMN1 that severely decreases its inclusion in the final mRNA, leading to an unstable SMN protein (Figure 3A).24 Nusinersen is an 18-mer, fully modified 2′MOE-PS (Figure 1) that was designed to bind to position +10 of...
Molecular Profiling of Individual FDA-approved Clinical Drugs Identifies Modulators of Nonsense-mediated mRNA Decaydoi:10.1016/j.omtn.2021.12.003Jingrong ZhaoZhelin LiRuchira PuriKelvin LiuIsrael NunezLiang ChenSika ZhengElsevier
mRNA measurements and antibody-based protein experiments to identify the distribution of the brain-specific genes and their expression profiles compared to other tissue types53). Overall, 100 of the 515 (~19%) of the rat target models were retained after this filtering step (full list provided ...
Gemcitabine and pemetrexed are clinically approved antimetabolites for the therapy of mesothelioma diseases. These drugs are often applied in combination with platinum complexes and other drugs. The activity of antimetabol
(macrophages, microglia, mast cells and T cells) to chronic pain. Given the urgent need to address the Pain crisis, we provocatively propose to repurpose/reposition FDA-approved immunomodulatory drugs for their potential to alleviate chronic pain. Repositioning or repurposing offers an attractive way ...