Altered microglial response to Abeta plaques in APPPS1-21 mice heterozygous for TREM2. Mol. Neurodegener. 9, 20.Ulrich JD, Finn MB, Wang Y, Shen A, Mahan TE, Jiang H, Stewart FR, Piccio L, Colonna M, Holtzman DM (2014) Altered microglial response to Abeta plaques in APPPS1-21 ...
In preceding efforts, we demonstrated that antibiotic (ABX) cocktail-mediated perturbations of the gut microbiome in two independent transgenic lines, termed/and APPPS1-21, leads to a reduction in A尾 deposition in male mice. To determine whether these observed reductions of cerebral A尾 ...
2023年12月,汤荟冬主任医师团队在《Gut Microbes》杂志在线发表题名为“Multi-omics data reveals aberrant gut microbiota-host glycerophospholipid metabolism in association with neuroinflammation in APP/PS1 mice.”——多组学数据揭示APP/PS...
Mice underwentin vivoμPET imaging at 2, 4, and 7 days post injection and were sacrificed at the end of each time point to assess brain penetrance, plaque labeling, biodistribution, and tracer stability. To confirm imaging specificity we also evaluated brain uptake of a non-amyloid targeting ...
APP/PS1 mice or wild-type C57BL/6 mice were intragastrically administered EA (50 mg/kg/day) or vehicle for 60 consecutive days. The learning and memory abilities of mice were investigated using the Morris water maze test. Hippocampal regions were examined for the presence of amyloid plaques,...
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These tentative results suggest that chronic, rather long-term MAGL inhibition can decelerate pathological changes in TG APP/PS1-21 mice but it improves memory functions only when administered at an early stage of theRea PihlajaPET Preclinical LaboratoryNoora LindgrenMedicity Research LaboratoryAnnamari ...
We have used FMT studies using our current short‐term abx APPPS1 mice to evaluate the microbiome﹎icroglia゛myloidosis axis. Short‐term, postnatal abx (4mg/ml Kanamycin, 0.35mg/ml Gentamicin, 8500U/ml Colistin, 2.15mg/ml Metronidazole, 0.45mg/ml Vancomycin: post‐natal day 14 to day ...
Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2. Molecular neurodegeneration 2014;9:20.Ulrich JD,Finn MB,Wang Y,et al. Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2[J]. Mol Neurodegener,2014,9:20....
Imaging amyloid plaque deposition with [18F]AV45 in living APP/PS1-21 miceAlzheimer's disease, the most common age-related neurodegenerative disorder, is characterized by the invariant cerebral accumulation of -amyloid peptide. In humans, [18F]-AV-45-PET is currently studied to follow-up in ...