Altered microglial response to Abeta plaques in APPPS1-21 mice heterozygous for TREM2. Mol. Neurodegener. 9, 20. https://doi.org/10.1186/1750-1326-9-20Ulrich JD, Finn MB, Wang Y, Shen A, Mahan TE, Jiang H, et al. Altered microglial response to Abeta plaques in APPPS1-21 mice ...
2023年12月,汤荟冬主任医师团队在《Gut Microbes》杂志在线发表题名为“Multi-omics data reveals aberrant gut microbiota-host glycerophospholipid metabolism in association with neuroinflammation in APP/PS1 mice.”——多组学数据揭示APP/PS...
Malm TM, et al. Pyrrolidine dithiocarbamate activates Akt and improves spatial learning in APP/PS1 mice without affecting beta-amyloid burden.J Neurosci. 2007 Apr 4; 27 (14):3712-21.Minkeviciene R, et al. Age-related decrease in stimulated glutamate release and vesicular glutamate transporters ...
一、品系名称品系名称：SAMP8 Mice别名：SAMP-8, SAM-P/8, SAM-P8毛色：白化编辑类型：自发突变疾病...
APP基因位于染色体21q11.2-22.2上，由18个外显子和17个内含子组成。基因产物为跨膜糖蛋白，由APP...
of gastro-intestinal microbes on the development of AD is not known and has also not adequately been addressed in model system despite often anecdotal evidence that amyloid plaque formation in APP transgenic mice differs among mouse facilities with different specific-pathogen-free (SPF) conditions21,...
In addition, APP/PS1 mice are commonly used in studying ethanol-induced AD pathology19,20. Cortical and hippocampal astrocyte reactivity is related to the development of AD21. Astrocytes synthesize ApoE and cholesterol, regulating cholesterol-dependent signaling in the brain22. In humans, the ...
Effects of Isopimaric Acid on cognitive handicap and synaptic plasticity in APP/PS1 mice Wang Li Tang Zuoqing Jia Jun Jiao Jinsong Liu Zunjing Li Xudong Duan Xiaohui Dong Mingrui Xia Qisheng Wang Kang Authors Info & Affiliations Published: 2016 -12 -20 · DOI: 10.3760/cma....
关键词 地黄饮子;肠脑轴;神经功能;学习记忆能力;APP/PS1 转基因阳性小鼠 Investigation of the improvement effect of Dihuang yinzi on neurological function of APP/PS1 double transgenic positive mice based on gut-brain axis and its mechanism CHEN Jing1,LIANG Xicai2,WANG Jian2,WANG Shenghua2,NING ...
(LP) improves cognitive impairment in 5XFAD and aged mice by regulating NF-κB-mediated BDNF expression. It was also found that treatment with LP can alleviate intestinal barrier damage and inhibit microglial activation. Therefore, increasing the abundance of LP in the intestine is of great ...