The present invention relates to the discovery of a toxin-antitoxin system in opportunistic human pathogen and to the applications of this discovery including the stabilization of plasmids useful in the field of recombinant DNA technology for production of genes and their products. The Phd-like (...
Using Peptides encapsulated in Rhamnolipid Liposomes for agriculture applications. The chemically synthesized peptide ParE3, is an analogue from the ParE protein that acts on a Toxin-Antitoxin system. This application inhibits DNA Gyrase and Topoisomerase IV (Topo IV) activities, blocking the DNA ...
Shedding is a process mediated by membrane-anchored metalloproteases in which the extracellular domain of an antigen is released from the cell membrane [16]. Upon analysis of reported examples of pH-responsive antibodies, a clear correlation between the designed pH-dependent mode of action and the ...
The Functional Annotation of Prokaryotic Taxa (FAPROTAX,http://mem.rcees.ac.cn:8080/) pipeline was used to extrapolate bacterial community functions relating to nutrient cycling (i.e., C, N, and S in the study) (Djemiel et al.2022; Ling et al.2022; Louca et al.2016). For P cyclin...
other side, it will overview the potentials of the different classes of single-domain antibodies that developed massively in the last two years, such as immunoaffinity, assisted crystallography, protein aggregation and activity tuning, and toxin inactivation, for which a systematic update is now ...
Other bacterial ense systems that have been studied or discovered by NGS include the toxin/anti-toxin, antigen, novel restriction-modification, and DNA phosphorathioation systems as well as those involved with infection-induced dormancy or programmed cell death [192]. Genomic sequencing also has ...
A major aspect of microbial metabolic engineering is the development of chassis hosts that have favorable global metabolic phenotypes, and can be further engineered to produce a variety of compounds. In this work, we focus on the problem of decoupling growth and production in the model bacteriumEsc...
3. The neutralizing monoclonal antibody or the antigen-binding fragment thereof of claim 1 or 2, wherein the neutralizing monoclonal antibody or the antigen-binding fragment thereof binding immune-specifically with tetanus toxin, and the neutralizing monoclonal antibody or the antigen-binding fragment th...
“Toxin-Antitoxin Genes of the Gram-Positive Pathogen Streptococcus pneumoniae: So Few and Yet So Many” Microbiology and Molecular Biology Reviews, 2012, 76(4):773-791. Chang, et al. “Genome editing with RNA-guided Cas9 nuclease in Zebrafish embryos” Cell Research, 2013, 23:465-472. ...
To overcome this, the bacteria have evolved with the production of a molecule, referred to as antitoxin, to negate the deleterious effect of the toxin against itself. The toxin and antitoxins are encoded by a two-component toxin-antitoxin (TA) system. The antitoxin, a protein or RNA, ...