Programmed necrosis in inflammation: toward identification of the effector molecules. Science. 2016;352:aaf2154. Article PubMed CAS Google Scholar Linkermann A, Brasen JH, Darding M, Jin MK, Sanz AB, Heller JO, et al. Two independent pathways of regulated necrosis mediate ischemia-reperfusion...
Types of Cell Death: Apoptosis, Autophagy, and Necrosis Decades of research have allowed for the detailed characterization and classification of the myriad ways that cells can self-destruct. The demise of a cell can sometimes be caused by rapid overwhelming external influences, as would be the cas...
Apoptosis was long thought to be the only regulated cell death pathway. In addition, its counterpart necrosis was considered to be rather ‘clumsy’ and to culminate with the loss of membrane integrity and passive leakage of intracellular contents. It has now become clear that a nonapoptotic form...
The relative importance of apoptosis and necrosis in the induction of macrophage mortality by these metal ions remains to be investigated. 展开 关键词: Metal ions Cobalt-chromium-molybdenum (CoCrMo) alloys Macrophages Apoptosis In vitro DOI: 10.1016/S0142-9612(02)00351-4 ...
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a member of the TNF family. The interaction of TRAIL with death receptor 4 (DR4) and DR5 can trigger apoptotic cell death. The aim of this study was to investigate the role of TRAIL signaling in neonatal hypoxia-ischemia (HI...
Jin-Gui-Shen-Qi Wan (JGSQ) has been used in China for thousands of years to treat various ailments, including frequent urination, blurred vision, and soreness in the waist and knees. It has traditional therapeutic advantages in improving eye diseases. Cl
It is known that inflammation can induce intracardiac volume depletion, inducing more rapid heart rate and reduced size of cardiac chambers. Additional effects of Lcn2, such as changes in cardiac metabolism, which are still unknown, may also contribute to functional parameters we measured here using...
2013, Cold Spring Harbor Perspectives in Biology Programmed cell death pathways in cancer: A review of apoptosis, autophagy and programmed necrosis 2012, Cell Proliferation View all citing articles on Scopus ☆ This article is part of a Special Issue entitled Mitochondria: the deadly organelle. ...
Necrosis. Necrosis is characterised by severe patho- physiological changes including mitochondrial swelling, plasma- lemmal disruption and ultimately leakage of cellular contents. The latter triggers acute exudative inflammation of the surrounding tissue; subsequent activation and infiltration of neutrophils is...
Apoptosis is an early, chronic, and temperate response subsequent to injury induction, whereas necrosis is an acute and severe reply. Causative factors of liver injury may induce both modes of cell death dependent on the severity of the insult. Apoptotic cells are characterized by energy-dependent...