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Apolipoprotein E and Alzheimer diseasedoi:10.1016/0197-4580(94)93069-4Gagnon, HugoFranck, JulienWisztorski, MaxenceDay, RobertFournier, IsabelleSalzet, MichelELSEVIERNeurobiology of Aging
Background Apolipoprotein E (APOE) is a well-known genetic risk factor for Alzheimer's disease (AD). APOE is now being investigated at the protein level, and studies indicate the levels of this protein may reflect disease status as well. Therefore, plasma APOE has been measured as a ...
Alzheimer's disease (AD) is a devastating neurodegenerative disorder that causes progressive cognitive decline. The majority of AD cases are sporadic and late-onset (>65 years old) making it the leading cause of dementia in the elderly. While both genetic and environmental factors contribute to th...
APOE, which encodes apolipoprotein E, is the most prevalent and best established genetic risk factor for late-onset Alzheimer’s disease. Current understanding of Alzheimer’s disease pathophysiology posits an important role for apolipoprotein E in the disease cascade via its interplay with β-amyloid...
eAppendix. Data Set Descriptions eFigure 1. Forest Plots of the Log Odds Ratios of Developing Alzheimer Disease for Men and Women with the APOE ε3/ε4 Genotype from 22 Independent Studies from Ages 55 to 85 eFigure 2. Forest Plots of the Log Odds Ratios of Developing Mild Cognitive Impai...
Fig. 1: Hypothesized role of apolipoprotein E (APOE) and lymphatic vessels in Alzheimer disease (AD). Schematic depiction of mouse ApoE and human APOE isoforms (top right), with yellow indicating the presence of cysteine [C] and blue indicating the presence of arginine [R]. Illustration of ...
Objectives: To explore the possible role of serum lipoprotein(a) (Lp(a)), apolipoprotein E polymorphism, and total cholesterol (TC) serum concentrations in Alzheimer's disease (AD). Methods: Lp(a) serum concentrations, apolipoprotein E genotypes, and TC serum concentrations were determined in 61...
Apolipoprotein E is a polymorphic and multifunctional protein with numerous roles in lipoprotein metabolism. The three common isoforms apoE2, apoE3 and apoE4 show isoform-specific functional properties including different susceptibilities to diseases. ApoE4 is an accepted risk factor for Alzheimer's disea...
A growing body of research has examined the relationship between episodic memory decline, the cognitive hallmark of Alzheimer's disease (AD), and the presence of Apolipoprotein E ε4 (APOE ε4) allele, a major genetic risk factor for the disease. Our review attempts to summarize and critically...