QH Meng,L Calabresi,JC Fruchart,YL Marcel 摘要: The reaction of highly purified lecithin:cholesterol acyltransferase (LCAT) with defined reconstituted discoidal apoA-I-containing lipoproteins (LpA-I) with 2, 3, or 4 apoA-I molecules/particle (Lp2, 3, or 4A-I) has been studied in the ...
SR-BI and HDL interaction has also been shown to activate the PI3K and ERK1/2 pathways in breast cancer [129]. In addition, interactions with PDZ domain containing 1 (PDZK1), a molecule that stabilizes SR-BI and promotes its translocation to the plasma membrane, may mediate several other ...
Analyzes the domain structures of lipid-free and lipid-bound apolipoprotein A-I (apo A-1) containing reduced and oxidized methionines by limited proteolysis. Description of apo A-1, composition and role; Definition of LCAT and function; Uses of limited proteolysis.Roberts...
ELISA系列丨载脂蛋白(Apolipoprotein) (Apolipoprotein)是脂蛋白(lipoprotein)中的蛋白质部分(图1)。载脂蛋白的主要功能是作为脂蛋白的结构成分,通过血液和淋巴运输脂质。载脂蛋白的合成发生在肠道和肝脏。他们的合成受饮食中脂肪含量和其他内部因素的调节。载脂蛋白除了作为脂蛋白的结构成分外,还作为细胞表面受体的配体和...
载脂蛋白(Apolipoprotein)是脂蛋白(lipoprotein)中的蛋白质部分(图1)。载脂蛋白的主要功能是作为脂蛋白的结构成分,通过血液和淋巴运输脂质。载脂蛋白的合成发生在肠道和肝脏。他们的合成受饮食中脂肪含量和其他内部因素的调节。载脂蛋白除了作为脂蛋白的结构成分外,还作为细胞表面受体的配体和酶的辅助因子。
It is possible that the major route of clearance of the lipoproteins containing apoE4–202, which contains only the 142–147 heparin binding domain, is via the LDL receptor and LRP pathways without the involvement of the heparan sulfate proteoglycan pathway. The potential participation of the LRP...
When 90% confluent, the cells were plated into 12-well plates (3 × 104 cells/mL) and cultured in MEM-α containing 2% (v/v) horse serum for 4–5 days. Differentiation into myotubes was monitored by phase contrast microscopy. Glucose uptake by HSKMCs Fully differentiated HSKMCs were...
The N-terminal sequence containing the 4H1 epitope has been positioned close to the central domain containing the epitopes for A11 and 5F6 to reflect the close structural (immunochemical) and functional properties of these domains as indicated in the text. In the N-terminal third of apoA-I, ...
Besides, Apo AI increases 3β-hydroxysteroid-Δ24 reductase (DHCR24) level by interacting with SR-BI and PDZ-domain-containing protein 1 (PDZK1), provoking phosphorylation of PI3K/Akt to trigger HO-1 expression to inhibit oxidative stress80....
Whether TbKIFC1 also transports APOL1-containing endosomes to the trypanosome plasma membrane, thereby inducing APOL1-mediated toxic cation fluxes [18,30] remains unproven. Such cation fluxes, mediated or not by APOL1, could contribute to trypanosome apoptotic-like death, but conversely, they could...