Apolipoprotein A-1 (ApoA-1) is a surface marker of brain HDL-like particles associated with the time of PD onset. Clinical correlates of serum Apolipoprotein A1 levels with structural brain connectivity in PD-related disordersremains unclear. Here, we applied a novel diffusion-weighted imaging ...
例句Animals without functioning apolipoprotein genes, which normally help control the production and activity of certain fats in the bloodstream, experienced runaway brain inflammation and nerve damage.有效的载脂蛋白基因通常有助于控制血流中某种脂肪的产生和活动,缺乏该种基因的动物,其脑部炎症和神经损伤会无...
In the brain, ApoE is synthesized by astrocytes under the regulation of LXR/RXR. Heterodimer of LXR/RXR interacts with DNA elements near the promotor of ABCA1, ABCG1, and APOE and upregulates their expression. When astrocytes release ApoE, it binds to the lipids (cholesterol and phospholipids...
"Independent protein-profiling studies show a decrease in apolipoprotein A1 levels in schizophrenia CSF, brain and peripheral tissues". Mol Psychiatry. doi:10.1038/sj.mp.4002108. PMID 17938634. ^ Wehmeier K, Beers A, Haas MJ, Wong NC, Steinmeyer A, Zugel U, Mooradian AD (2005). "...
Advantages of unique peptides as stroke biomarkers are as follows: first, they represent both the integral and fragmental endogenous protein pools in the blood; second, peptides and small fragments of proteins move freely across the blood brain barrier (BBB) and can be detected in the serum [...
Lipopolysaccharide enters the rat brain by a lipoprotein-mediated transport mechanism in physiological conditions 2017, Scientific Reports A new cryptic cationic antimicrobial peptide from human apolipoprotein E with antibacterial activity and immunomodulatory effects on human cells 2016, FEBS Journal Detoxifying...
Lack of ABCA1 considerably decreases brain ApoE level and increases amyloid deposition in APP23 mice. J. Biol. Chem. 280, 43224–43235 (2005). Article CAS PubMed Google Scholar Wahrle, S. E. et al. Deletion of Abca1 increases Abeta deposition in the PDAPP transgenic mouse model of ...
Winiewski a - 《Brain Research》 被引量: 158发表: 1995年 Proteomic biomarkers apolipoprotein A1, truncated transthyretin and connective tissue activating protein III enhance the sensitivity of CA125 for detecting... 80% of ovarian cancers are diagnosed in late stage as symptoms are common and go...
Apolipoprotein A1 (ApoA1) is the major apoprotein constituent of high-density lipoprotein that can play important roles in tumor invasion and metastasis. The objective of the present study was to evaluate the association of two genetic variants (-75 G/A and +83 C/T) of APOA1 with predispos...
with apoA-IIowa fibrils (Fig. 3a), which suggests that apoA-IIowa fibrils caused a reduction in lysosomal (ROWSe)39a.lsLoysporseovmioaulsmlyesmhobwraendetpheartmapeoabAi-liIzIoawtaiofinbrainlsdcsauubsseedquinecnrtecaysetodspolriocdruecletaiosne of of reactive oxygen species lysosomal ...