乙型肝炎病毒共价闭合环状DNA(HBV cccDNA)超突变干扰素刺激基因乙型肝炎病毒共价闭合环状DNA(Hepatitis B virus covalently closed circular DNA,HBV cccDNA)是乙肝病毒基因组存在于受感染肝细胞中高度稳定和持久的形式,是病毒清除失败和目前抗病毒治疗停止后病毒学复发的原因之一.作为天然宿主病毒限制因子,载脂蛋白B mRNA...
et al. Activities of endogenous APOBEC3s and uracil-DNA-glycosylase affect the hypermutation frequency of hepatitis B virus cccDNA. J. Gen. Virol. 103, https://pubmed.ncbi.nlm.nih.gov/35438620/ (2022). Schlee, M. & Hartmann, G. Discriminating self from non-self in nucleic acid sensing....
APOBEC3家族减少乙型肝炎病毒cccDNA库的作用机制进展 乙型肝炎病毒共价闭合环状DNA(Hepatitis B virus covalently closed circular DNA,HBV cccDNA)是乙肝病毒基因组存在于受感染肝细胞中高度稳定和持久的形式,是病毒清除... 张泽凤,李晖,邓秀秀,... - 《病毒学报》 被引量: 0发表: ...
Heikenwalder, U. Protzer Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA Science, 343 (2014), pp. 1221-1228 CrossrefView in ScopusGoogle Scholar Cited by (49) The role of Nuclear Factor-kappa B signaling in human cervical cancer 2017, Critical Reviews in Oncology/...
In conclusion, HBx-elevated MSL2 modulates HBV cccDNA in hepatoma cells to promote hepatocarcinogenesis, forming a positive feedback loop of HBx/MSL2/cccDNA/HBV. Our finding uncovers novel insights into the mechanism by which MSL2 as a promotion factor in host cells selectively activates ...
Twelve days of treatment with a LT尾R-specific agonist BS1 is sufficient to reduce the cccDNA pool by 80% without inducing significant damages to a subset of cancer-related host genes. Interestingly, the A3B-mediated effect on HBV is independent of the transcriptional activity of cccDNA as ...
cccDNAreservoirHIF1αNew therapeutic strategies against Hepatitis B virus (HBV) focus, among others, on the activation of the immune system to enable the infected host to eliminate HBV. Hypoxia inducible factor 1 alpha (HIF1α) stabilisation has been associated with impaired immune responses. HBV ...
p-STAT3-elevated E3 ubiquitin ligase DTX4 confers the stability of HBV cccDNA by ubiquitinating APOBEC3B in liverdoi:10.7150/thno.99407Lina ZhaoHongfeng YuanYufei WangChunyu HouPan LvHuihui ZhangGuang YangXiaodong ZhangTheranostics
Recently, it was reported that APOBEC3B can edit HBV cccDNA in the nucleus, causing its degradation. However, whether and how it can edit HBV core-associated DNAs during reverse transcription is unclear. Our studies to address this question revealed the following: First, silencing endogenous ...
The APOBEC3-induced HBV mutations were predominantly detected in the HBV rcDNA but were not detectable in other intermediates including HBV cccDNA and pgRNA by primer extension of their PCR amplification products. These data demonstrate that APOBEC3-induced HBV genome mutations occur predominantly when ...