The 1.8 Å resolution structure (PDB 4TRM) displays six molecules in the asymmetric unit, four of them forming a tetramer that obeys 222 symmetry [8]. Such tetrameric arrangement results in the formation of 2 types of interface. The first type of interface buries approximately 1474 ...
Fig. 2. The NADP(H)-binding site in the dIII crystal structure of the bovine mitochondrial TH (PDB code 1D4O). Bound NADP(H) is shown as a ball and stick structure with the nicotinamide moiety to the left and the adenine moiety to the right. Residues Lys424–Arg425–Ser426 binding...
versus the [intact α-crystallin]/[apoPhb] ratio plot is indicative of the decrease in the AC of α-crystallin with increasing the [α-crystallin]/[αpoPhb] ratio and can be interpreted as an evidence for dynamic chaperone structure and polydispersity of α-crystallin-target protein complexes....
Here,we use protein structure modelling, molecular dynamics (MD) simulations combined with multi-wavelength analytical ultracentrifugation (MWA-AUC) and small angle X-ray scattering (SAXS) experiments to derive a consensus model of the LPOR apoprotein and the substrate/cofactor/LPOR ternary complex. ...
- 《Proteins-structure Function & Bioinformatics》 被引量: 84发表: 2002年 Loss of TAL-1 protein activity induces premature apoptosis of Jurkat leukemic T cells upon medium depletion. Transcriptional activation of the tal-1 gene occurs in -30% of patients with T cell Acute Lymphoblastic Leukemia ...
Insights into the structure and aggregation of lens crystallins and other aggregation-prone proteins Cataract is the world's leading cause of blindness. The destabilization, partial unfolding, and aggregation of lens crystallin proteins cause the loss of l... A Grosas 被引量: 0发表: 2020年 Macr...
Rather, binding results in the stabilization of essential parts of the structure, such as those involved in dimer stabilization. Altogether, this structure represents the example of an apo-form of an NTR that yields important insight into the effects of the cofactor on protein folding.View Full-...
ZnPP is a potent enzyme inhibitor, and the ZnPP-bound structure of HO-1 mimics the heme-bound structure. These assignments provide the structural basis for a detailed investigation of the HO-1 function. 展开 关键词: Heme oxygenase NMR resonance assignments Cellular homeostasis Heme protein ...
Proteins: Structure, Function, and BioinformaticsStructure and properties of a truely apo form of AraC dimerization domain. Proteins 66:646–654 - Weldon, Rodgers, et al. - 2007 () Citation Context ...ow known from the X-ray structure of the dimerization domain of AraC and the nuclear ...
The data were processed with CDNN, CD Spectra Deconvolution Program and percentages of secondary structure elements were found to be: 12% of α-helix, 56% of β turn, antiparallel and parallel β sheets and 32% of random structures, after proteins association with AgNPs. Show abstract On the...