IF:14.714)发表了题为“A Dual Function of Ferritin (Animal and Plant): Its Holo Form for Iron Supplementation and Apo Form for Delivery Systems”的综述论文。
K. (2002). The structure of apo and holo forms of xylose reductase, a dimeric aldo-keto reductase from Candida tenuis. Biochemistry 41, 8785-8795.Kavanagh KL, Klimacek M, Nidetzky B, Wilson DK: The structure of apo and holo forms of xylose reductase, a dimeric aldo-keto reductase from...
andexperimentalsolutionstructuresofholo-FABP,butanumberof differencesareobservedfortheapo-form.Theligandinholo-FABP showsconsiderabledisplacementafterabout1.5nsanddisplayssigni®- cantcon®gurationalentropy.Anovelcomputationalapproachhasbeen employedtoidentifyinternalwaterandtocaptureexchangepathways. ...
与小分子配体结合通道的构象变化-Apo和holo甲状腺结合前清蛋白分子动力学模拟 获取原文 页面导航 摘要 著录项 相似文献 相关主题 摘要 Transthyretin (TTR) tetramer is an important transporter of thyroxine both In plasm and CSF,thyroxine and Its analogues bind with TTR at its central binding channel divi...
align both apo- and holo-proteinsto the query holo protein Given the apo form of a protein(a protein structurewithout any ligands): findall other forms of that protein that bind at least one ligand (holo-proteins). findall other unbound forms of that protein (apo-proteins) that completely...
Unexpectedly, this novel class of IDO1 inhibitor does not target the holo form of IDO1 protein but displaces heme and binds to its apo form. Representative compound I-4 exhibits moderate potency with IC50 value of 0.44 μM in cell-based IDO1 assay, which has the potential to be developed...
Margulis (1993)defined the term as, ‘The holobiont is the product, temporary or permanent, of the association between its constituent bionts (partners)’.Iglesias-Prieto and Trench (1997)usedholosymbiontto describe highly integrated systems where host and symbiont evolve together.Holobiontwas adopted...
The apoprotein has a topology similar to the holoprotein. Nevertheless, significant differences in helix−helix packing between the two are evident. Much of the haem binding pocket in the apoprotein is preserved but exposed to solvent creating a large cavern. As apocytochrome b <sub>562</sub>...
An apo form of cytochrome c550 can be detected by immunoblotting cell-free extracts of a mutant of Paracoccus denitrificans that is deficient in c-type cytochromes. This apoprotein is found predominantly in the periplasm, the location of the holocytochrome in the wild-type organism, indicating ...
Conformational Transitions upon Ligand Binding: Holo-Structure Prediction from Apo Conformations Biological function of proteins is frequently associated with the formation of complexes with small-molecule ligands. Experimental structure determination ... D Seeliger,BL De Groot,T Lengauer - 《Plos Computatio...