APH1A是γ-分泌酶复合物的一个重要亚单位,它是一种内蛋白酶复合物,催化如Notch受体和APP(β-淀粉样蛋白前体蛋白)等完整蛋白的膜内裂解。它可能是促进稳定复合物形成的早老素同二聚体的稳定辅助因子。属于APH-1家族。 功能: γ-分泌酶复合物的基本亚单位,一种内蛋白酶复合物,催化如notch受体和app(β-淀粉样...
APH1A 导读 基因简介 中英文全称:前咽缺陷1 同源物A(秀丽线虫) anterior pharynx defective 1 homolog A (C. elegans) 分布:内质网|高尔基堆叠| 融入质膜|膜 活性:蛋白结合 参与:膜蛋白胞外域蛋白水 解|Notch 受体加工|蛋白加工|膜蛋白细胞内域蛋白水解|淀 粉状蛋白前体蛋白分解代谢|正调控酶 OMIM/位置:607629 ...
and Notch receptors in addition to the A-beta peptide from the amyloid precursor protein (APP). Alternate splicing generates a short isoform of human APH1A that lacks 18 amino acids at the C-terminus. Within aa 58-69, human APH1A shares 100% aa sequence identity with mouse and rat APH1A...
Transcriptional regulation of APH-1A and increased gamma- secretase cleavage of APP and Notch by HIF-1 and hypoxia. FASEB J. 2006; 20:1275-1277. [PubMed: 16645044]Wang R,Zhang Y W,Zhang X,et al.Transcriptionalregulation of APH-1A and increased gamma-secretasecleavage of APP and Notch by...
APH1a is an essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursorAnti-APH1a抗体protein). It probably represents a stabilizing cofactor for the presenilin homodimer ...
this gene encodes a component of the gamma secretase complex that cleaves integral membrane proteins such as notch receptors and beta-amyloid precursor protein. the gamma secretase complex contains this gene product, or the paralogous anterior pharynx defective 1 homolog b (aph1b), along with the ...
The γ-secretase complex, including presenilin homodimer, nicastrin, APH1A, and PSENEN/PEN2, catalyzes the cleavage of intramembrane proteins such as Notch and APP. APH1A Protein, Human (Cell-Free, His, SUMO) is the recombinant human-derived APH1A protein, expressed by E. coli Cell-free , ...
APH1A 蛋白是 γ-分泌酶复合物的非催化亚基,对于该内切蛋白酶的组装至关重要。γ-分泌酶复合物,包括早老素同型二聚体、尼卡斯特林、APH1A 和 PSENEN/PEN2,催化膜内蛋白(如 Notch 和 APP)的裂解。APH1A Protein, Human (Cell-Free, His, SUMO) 是重组的 APH1A 蛋白,由 E. coli Cell-free 表达,带有 ...
背景说明: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the...