In vitro在qHTS分析中,APE1-IN-1展示出2 μM的IC50,而在放射性示踪剂切割分析(RIA)中,其IC50为12 μM[1]。APE1-IN-1以剂量依赖方式(浓度为0、1、3、10、30或100 μM,时间为15分钟)抑制HeLa全细胞提取物中AP位点的切割[1]。此外,在24小时内,APE1-IN-1(浓度范围5至30 μM)对HeLa细胞显示出细胞...
英文名称 APE1-IN-1 生化机理 APE1-IN-1 是一种具有血脑屏障(BBB)穿透力的强效嘌呤/嘧啶(AP)内切酶 1(APE1)抑制剂,其 IC 50 值为 2 μM。APE1-IN-1 能增强烷化剂甲磺酸甲酯和替莫唑胺的细胞毒性。 储存温度 -20°C储存 运输条件 超低温冰袋运输 产品介绍 APE1-IN-1 is a potent and ...
APE1-IN-1 是一种有效且具有血脑屏障透过性的无嘌呤/嘧啶内切酶 1 (APE1) 抑制剂,IC50 为 2 μM。APE1-IN-1 可增强烷基化剂甲基甲烷磺酸盐 (Methylmethane sulfonate) 和 Temozolomide (HY-17364) 对癌细胞的细胞毒性。 详细介绍 产品活性:APE1-IN-1 是一种有效且具有血脑屏障透过性的无嘌呤/嘧啶...
化合物 APE1-IN-1 CAS号: 524708-03-0 英文名: APE1 Inhibitor III 英文别名: APE1-IN-1;APE1 Inhibitor III;N-(3-(Benzo[d]thiazol-2-yl)-6-isopropyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)acetamide;Acetamide, N-[3-(2-benzothiazolyl)-4,5,6,7-tetrahydro-6-(1-...
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Single Nucleotide Polymorphisms in APE1, hOGG1, RAD51 Genes and their Association with Radiotherapy Induced Toxicity among Head and Neck Cancer Patientsdoi:10.31557/APJCP.2024.25.8.2645Gudur, Anand K.Kale, Shivani R.Gudur, Rashmi A.Bhosale, Suresh J....
DapE-IN-1 (compound 3y) 是⼆氨基庚⼆酸脱琥珀酰酶 (DapE) 抑制剂，是潜在的强效抗⽣素。Caution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792***Fax: ***E-mail: *** 1/1Master of Bioactive Molecules —您⾝边的抑制剂⼤师...
Apurinic/apyrimidinic endonuclease 1 (APE1) is a DNA repair protein, which plays important roles in the base excision repair (BER) pathway. Genetic variations of APE1 have been shown to influence an individual's susceptibility to carcinogenesis. We hypothesized the genetic polymorphisms of APE1 ...
Apurinic/apyrimidinic endonuclease 1 (APE1) has a central role in the repair of apurinic apyrimidic sites through both its endonuclease and its phosphodiesterase activities. A commonAPE1polymorphism, T1349G (rs3136820), was previously shown to be associated with the risk of cancers. We hypothe...
中文名称: 化合物 APE1-IN-1 中文同义词: 化合物 APE1-IN-1;APE1抑制剂1;N-(3-(苯并[D]噻唑-2-基)-6-异丙基-4,5,6,7-四氢噻吩并[2,3-C]吡啶-2-基)乙酰胺 英文名称: APE1 Inhibitor III 英文同义词: APE1 Inhibitor III;Acetamide, N-[3-(2-benzothiazolyl)-4,5,6,7-tetrahydro-6...