然而,HCC中铁死亡调节的机制尚不清楚。2024年2月28日,南京师范大学郭志刚/胡志刚教授团队在Cell Death and Differentiation (IF 12.4)发表题为“APE1 inhibition enhances ferroptotic cell death and contributes to hepatocellular carcinoma therapy”的研究论文。研究揭示了多功能酶APE1在铁死亡调节中的新作用和机制,并...
然而,HCC中铁死亡调节的机制尚不清楚。2024年2月28日,南京师范大学郭志刚/胡志刚教授团队在Cell Death and Differentiation (IF 12.4)发表题为“APE1 inhibition enhances ferroptotic cell death and contributes to hepatocellular carcinoma therapy”的研究论文。研究揭示了多功能酶APE1在铁死亡调节中的新作用和机制,并...
At the molecular level, the inhibition of APE1 enhances ferroptosis which relies on the redox activity of APE1 through the regulation of the NRF2/SLC7A11/GPX4 axis. We have identified that both genetic and chemical inhibition of APE1 increases AKT oxidation, resulting in an impairment of AKT ...
et al. APE1 inhibition enhances ferroptotic cell death and contributes to hepatocellular carcinoma therapy. Cell Death Differ 31, 431–446 (2024). https://doi.org/10.1038/s41418-024-01270-0 Download citation Received03 August 2023 Revised11 February 2024 Accepted12 February 2024 Published28 ...
A similar inhibition pattern was observed with the homologous Escherichia coli protein, exonuclease III, but no inhibition was seen with the structurally distinct AP endonuclease E. coli endonuclease IV, indicating a targeted effect of Pb(II), Fe(II), and Cd(II) on the Ape1-like repair ...
Inhibition of APE1Ref-1 redox activity rescues human retinal pigment epithelial cells from oxidative stress and reduces choroidal neovascularization 文档格式: .pdf 文档大小: 1.16M 文档页数: 10页 顶/踩数: 0/0 收藏人数: 0 评论次数: 0 文档热度: ...
APE1-inhibition sensitizes TNBC cancer cells to Pt-salts treatment In order to address whether APE1 also plays a role in CDDP-cytotoxicity of TNBC cells, we used a targeting strategy with specific APE1 inhibitors. To this purpose, we used several inhibitors of APE1; specifically, we tested ...
www.nature.com/scientificreports OPEN received: 03 July 2015 accepted: 29 October 2015 Published: 07 December 2015 Inhibition of Ape1 Redox Activity Promotes Odonto/osteogenic Differentiation of Dental Papilla Cells Tian Chen1,2,3, Zhi Liu1,2, Wenhua Sun1,2, Jingyu Li1,2,3, Yan...
a small molecule redox inhibitor of APE1/Ref-1. Combination treatment of RA + E3330 results in a profound hypersensitivity of myeloid leukemia cells to RA-induced differentiation and apoptosis. Additionally, redox inhibition by E3330 results in enhanced RAR target gene, BLR-1, expression in myel...
(C) Inhibition of APE1 endonuclease activity in combination with treatment with rotenone sensitizes HeLa cells to apoptosis. Cells were treated with Compound #3 in the absence or presence of rotenone (0.5 and 5 µM), for 24 h. The Apo-ONE assay was used to quantify relative levels ...