研究发现,APC(抗原提呈细胞)表面蛋白和癌细胞表面的PD-L1同时与T细胞表面的PD-1(程序性细胞死亡蛋白-1)结合,从而阻止T细胞对癌细胞的免疫清除,PD-1抗体能
1.1对于表达在肿瘤表面的PD-L1:首先,作为PD-1的配体,PD-L1抑制剂与肿瘤表面的PD-L1结合,阻断PD-1/PD-L1的结合,解除T细胞的活化和增殖抑制,使肿瘤特异性T细胞处于活化状态,恢复T细胞的杀伤功能。 其次,PD-L1抑制剂具有阻断肿瘤细胞表面PD-L1与APC细胞表面B7-1的结合能力,有利于全面激活T细胞。 针对这一点,靶点...
High levels of PD-L1 expressed on tumor epithelial cells are one of the potential mechanisms by which tumor cells become resistant to immune attack. However, PD-L1 regulation in tumor cells is not fully understood. Here we demonstrate that mutations in the adenomatous polyposis coli (APC) gene...
Buy reliable, cost-effective APC Anti-Mouse CD274/PD-L1 Antibody[10F.9G2] for CD274 detection in flow cytometry. By CD274 marker to ideal identify target cell sorting or cell counting.
PD-L1 monoclonal antibody (APC), MAB23679-M01, highly specific and rigorously validated in-house for Immunocytochemistry (ICC/IF). PD-L1 monoclonal antibody (APC), MAB23679-M01 is ready to ship.
标记物:APC 品牌:BioLegend 包装规格:25 ug 抗原来源:大鼠 适应物种:小鼠 克隆性:是 标识物:科研研究 形态:液体 保存条件:2-8℃ 货号:124311 用途:科研研究 是否进口:是 anti-mouse CD274 (B7-H1, PD-L1) Antibody-APC详细如下: 124311anti-mouse CD274 (B7-H1, PD-L1) Antibody-APC抗小鼠CD274(B7-H1...
APC anti-mouse CD274 (B7-H1, PD-L1) Antibody 产品编号:124311 产品类别:牛ELISA试剂盒 检测样本:124311 规格 价格库存 25µg ￥ 881 立即订购 订购热线:021-34661276 收藏此商品 我要询价 Product Details Verified Reactivity Mouse Antibody Type
Print datasheet MSDS ¥2550/100tests Cat No.APC-65081 浓度:5 ul/test 库存:现货 点击咨询售前客服 点击咨询售后客服 See more citations
CD274 (PD-L1, B7-H1) Antibody (17-5983-42) in Flow Staining of unstimulated (left) or PHA-stimulated (right) normal human peripheral blood cells with Mouse IgG1 K Isotype Control APC (Product # 17-4714-81) (blue histogram) or Anti-Human CD274 (B7-H1) APC (purple histogram)...
APC anti-human CD274 (B7-H1, PD-L1) Isotype : Mouse IgG2b, κ Other Names : Programmed cell death ligand 1 (PD-L1), B7 homolog 1 (B7-H1) Size : 25 tests Price (USD) : 138 USD Reactivity : Human Clonality : Monoclonal Host : ...