Most cases of colorectal cancer (CRC) are initiated by inactivation mutations in the APC gene, which is a negative regulator of the Wnt-β-catenin pathway. Patients with familial adenomatous polyposis (FAP) inherit a germline mutation in one APC allele, and loss of the second allele leads to...
In addition, the progress of chemotherapy or radiotherapy can be monitored more easily by testing such body samples for mutant APC genes or gene products. The methods of diagnosis of the present invention are applicable to any tumor in which APC has a role in tumorigenesis. Deletions of ...
fat, and protein metabolism, and gene transcription, as a result of altered gene regulatory and transcription pathways, and also as a result of changes in cell-cell interactions. These are embodied in the following series of graphics.
The widespread application of colonoscopy screening and genetic testing in colorectal cancer (CRC) treatment has led to the identification of a subset of familial adenomatous polyposis (FAP) patients who lack a family history of the disease but harbor germline gene mutations. Moreover, distinct ...
We conclude that the colossal crypts at adenoma margins have normal Apc gene function, consistent with the suggestion that their phenotype is a reactive state. The cause remains an open question, but the dramatic epithelial response hints at the presence of potent epithelial trophic factors in the...
ML: Conception and design, acquisition of data, analysis and interpretation of data, writing of the manuscript, MB: Acquisition of data, analysis and interpretation of data. GO: Analysis and interpretation of data. RE: Statistical analysis. KJ: Acquisition of data, analysis and interpretation of ...
ApcMin/+ mice, a genetically engineered mouse model that has a mutation in the Apc gene, usually serve as a well-characterized animal model for human familial adenomatous polyposis [24]. Ki67 and Proliferating Cell Nuclear Antigen (PCNA) proteins are standard markers of cell proliferation, thus ...