It is also expressed on some tumor cancer cells. Function Inhibit T cell activation, cell cycle progression, and cytokine production. Cell Type B cells, Dendritic cells, Macrophages, T cells Biology Area Costimulatory Molecules, Immunology, Innate Immunity Antigen References 1. Choi IH, ...
作者:Floyd 导读:树突状细胞(Dendritic cells, DC)是机体功能最强的专职抗原递呈细胞(Antigen presenting cells, APC),它能高效地摄取、加工处理和递呈抗原,未成熟DC具有较强的迁移能力,成熟DC能有效激活初始型T细胞,处于启动、调控、并维持免疫应答的中心环节。 肿瘤免疫(tumor immunology),患肿瘤后机体对肿瘤的免疫反...
The EasySep™ APC Positive Selection Kit II is designed to isolate cells that are labeled with APC (allophycocyanin)-conjugated antibodies by positive selection. Desired cells are targeted with antibody complexes recognizing APC and dextran-coated magnetic particles. Labeled cells are separated using an...
Immunology View More Data Figures Figure 1.Purity of CD45+ Cells Following Cell Isolation with the EasySep™ Release Human APC Positive Selection Kit In the above example, the frequencies of CD45+ cells in the starting and isolated fractions are 5.9% and 94.2%, respectively. ...
他们先前已经证明了用转录因子PU.1、IRF8和BATF3(称为PIB)可以将小鼠和人成纤维细胞直接重编程为免疫原性cDC1细胞(Direct reprogramming of fibroblasts into antigen-presenting dendritic cells. Sci. Immunol.)。因此假设PIB可以将癌症细胞重编程为抗原呈递细胞(APC),从而提供了一种对抗肿瘤免疫逃避机制和恢复肿瘤细...
B cells, Dendritic cells, NK cells, Plasma cells, T cells Biology Area Cell Adhesion, Cell Biology, Immunology Molecular Family Adhesion Molecules, CD Molecules Antigen References 1. Ferrero E, et al. 1999. J. Leukoc. Biol. 65:151. 2. Lund F, et al. 1995. Immunol. Today 16...
Targeting antigen expression to antigen-presenting cells inactivates cognate CD8+ effector and memory T-cell responses and has therapeutic potential. Here we investigated this in the context of insulin-specific responses in the non-obese diabetic mouse where genetic immune tolerance defects could impact...
Flow cytometry, a powerful tool in immunology research, enables the quantification and characterization of APCs in complex mixtures. By labeling APCs with specific antibodies and fluorescent dyes, researchers can isolate and analyze these cells based on their surface markers and intracellular properties. ...
APC 抗原呈递细胞的种类与特点 CHENZONGDEDEPARTMENTOFMICROBIOLOGYANDIMMUNOLOGYCOLLEGEOFBASICMEDICALSCIENCEZHENGZHOUUNIVERSITY ANTIGENPRESENTINGCELL 抗原呈递细胞（antigenpresentingcell，APC）是指能够摄取、加工、处理抗原，形成免疫原性多肽并与其MHC分子结合成抗原肽-MHC分子复合物，供T淋巴细胞识别的细胞。种类 •...
Cells carrying a truncated APC gene ( ApcMin) are defective in chromosome segregation. During mitosis, APC localizes to the ends of microtubules embedded in kinetochores and forms a complex with the checkpoint proteins BUB1 and BUB3. In vitro , APC is a high-affinity substrate for BUB ...