1、后期促进复合物/细胞周期体(APC/C):大型、多亚基E3泛素连接酶复合物,在真核细胞周期调控中发挥关键作用。 2、Cdc20:一种关键的有丝分裂调节蛋白,与APC/C结合形成APC/C-Cdc20复合物,在有丝分裂过程中发挥重要作用。Cdc20的过度...
Here, by using weighted gene co-expression network analysis (WGCNA), we identified CDC20 as a hub gene in HCC. We demonstrated that CDC20 expression is correlated with HIF-1 activity and overall survival (OS) of clinic HCC patients. The activity of HIF-1 is regulated by the stability of...
答案:后期促进因子络合物是细胞分裂从后期向后期转化过程调控的重要中因子。后期促进因子络合物APC主要介导两类蛋白降解:后期脂质抑制因子和有丝分裂景气周期蛋白。前者维持姐妹染色单体黏连,抑制后期启动;后者的降解意味着有丝分裂即将完结,即染色体开始去凝集,核膜重建。APC可被Cdc20激活。但是,在有丝分裂前期,Cdc20和 ...
The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC - Cdc20 complex. Nat. Cell Biol. 6, 129 - 137.Song MS,Song SJ,Ayad NG,et al.The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex. Nature Cell Biology . 2004...
M-CDK复合物磷酸化APC/C：M-CDK复合物会磷酸化APC/C上的多个位点，使其变得活跃。Cdc20结合到活化的...
Dephosphorylation of Cdc20 is required for its C-box-dependent activation of the APC/CAPC/CCdc20CDKcell cyclephosphataseThe anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase is tightly regulated to ensure programmed proteolysis in cells. The activity of the APC/C is positively controlled...
Cdc20(cell division cycle 20 homologue)是一种细胞周期调节蛋白,在很多肿瘤中都有高表达,是关键的促癌因子,对有丝分裂进程特别是肿瘤干细胞的发展至关重要。因此开发特定的Cdc20抑制剂是改善人类癌症治疗的新策略。Apcin是目前唯一已报道的Cdc20特异性抑制剂,但其抗细胞增殖的能力较弱。 2020年4月15日,中南大学...
【题目】分裂后期促进因子APC的发现是细胞周期研究领域中又一重大进展.已知到分裂中期,位于动粒(纺锤丝附着位点)上的Mad2消失,解除对Cdc20的抑制作用,促使APC活化,参照如图所示的细胞周期,APC起作用是在()1分裂期G23GSDNA合成2A.1B.2C.3~4D.4~1
directed against Cdc20 induced an accumulation of E2F1 protein in prometaphase cells. These data suggest that APC/C(Cdc20) specifically targets E2F1 for degradation in early mitosis and reveal a novel mechanism for limiting free E2F1 levels in cells, failure of which may compromise cell survival ...