APC活性的调节:正调控因子:cdc20/Fizzy,Cdh1/Fzy负调控因子:Emi1、Emi2、Mad2、BubR1等。 Cdc20主要位于染色体动粒上,为姐妹染色单体分离所必需的Mad2正常情况下定位在早中期和错误排列的中期染色体的动粒上,所以纺锤体组装不完全,动粒不能被动粒微管捕捉,mad2则不能从动粒上解离下来。APC的活性还受到纺锤体组装...
目前已知[1]细胞中存在正负两种活性调节因子.正调节因子有Cdc20、Cdh1等，负调节因子有Emi1、Emi2、Mad...
APC15 is located near APC/C's MCC binding site; it is required for APC/C-bound MCC (APC/C(MCC))-dependent CDC20 autoubiquitylation and degradation and for timely anaphase initiation but is dispensable for substrate ubiquitylation by APC/C(CDC20) and APC/C(CDH1). Our results support the...
Anaphase Promoting Complex or Cyclosome (APC/C) is a representative E3 ubiquitin ligase, triggering the transition of metaphase to anaphase by regulating degradation and ensures the exit from mitosis. Cell division cycle 20 (CDC20) and Cell division cycle 20 related protein 1 (CDH1), as co-...
(APC/C), a ubiquitin ligase that plays an important role in cell cycle progression. Ectopic expression of the APC/C activators Cdh1 and Cdc20 reduced the levels of co-expressed E2F-1 protein. Co-expression of DP1 with E2F1 blocked APC/C-induced E2F1 degradation, suggesting that the E2F1/...
具体来说,cdc20和cdh1直接与apc结合并激活apc的细胞周期蛋白泛素化活性。相反,mad2通过与cdc20和apc形成三元复合物来抑制apc,从而阻止apc激活。APC11是一种环H2指蛋白,允许在存在泛素载体蛋白4(UBC4)和泛素结合酶(E2)的情况下合成多泛素链。此外,一种UBC4或UBCH10与APC11和APC2的异二聚体复合物可催化人二聚...
Multiprotein E3 ligase complex involved in the ubiquitylation of proteins for their degradation by the proteasome. It is activated by Cdc20 or Cdh1, which specify substrate recognition, promoting anaphase progression, mitotic exit, or the maintenance of G1. ...
TAME hydrochloride (Tos-Arg-OMe HCl) 是后期促进复合体(APC/C 或 APC)的抑制剂,可与 APC/C 结合并阻止其通过 Cdc20 和 Cdh1 活化,产生有丝分裂阻滞。它是一种 od 氨基酸衍生物。 Amino Acids and DerivativesAPC/C ¥ 128 现货 规格 数量
Cdh1 (also known as Hct1) and the cyclin-dependent kinase inhibitor Sic1 by the phosphatase Cdc14, allowing mitotic kinase inactivation and mitotic exit3,4,5,6,7. Here we show, however, that spindle disassembly and cell division occur without significant APCCdc20-mediated Clb5 degradation, ...
TAME是一种能够抑制后期促进复合体(APC/C或简称APC)功能的化合物,通过与APC/C结合,TAME能够阻止该复合体通过Cdc20和Cdh1进行活化,从而在有丝分裂过程中产生阻滞效果。 产品性质 英文别名 (English Synonym) TAME 中文名称 (Chinese Name) / 靶点 (Target) APC 通路 (Pathway) Cell Cycle/DNA Damage CAS号...