(2005). Structure of Apaf-1 in the auto-inhibited form: a critical role for ADP. Cell Cycle 4, 1001-1003.Bao Q,Riedl SJ,Shi Y.Structure of Apaf-1 in the auto-inhibitedform:a critical role for ADP. Cell Cycle . 2005Bao Q, Riedl SJ, Shi Y. 2005. Structure of Apaf-1 in the ...
when extracts ofApaf-1+/+but notApaf-1−/−IFETs were incubated with cytochromecand dATP, the Caspase-3 activation was observed (Supplementary Figure S1B), confirming that Apaf-1 was functionally inactivated by the deletion of its exon 5. TheApaf-1+/+andApaf-1...
It is published weekly and covers all aspects of the structure and function of Oncogenes. M Burek,S Maddika,CJ Burek,... - 《Oncogene》 被引量: 195发表: 2006年 Boo, a novel negative regulator of cell death, interacts with Apaf-1. In this report, we describe the cloning and ...
C Reddy,R Sankararamakrishnan - 《Proteins Structure》 被引量: 0发表: 2022年 Wang Xiaodong This allowed the biochemical purification a complex of Cytochrome c, Caspase-9 and the Apoptotic Protease Activating factor-1 (Apaf-1). These components ... LM Surhone,MT Tennoe,SF Henssonow,... - Be...
FIG. 2. Dimerization of pro-casp9 is sufficient for pro-casp9 proteolytic activation and induction of apoptosis. A, Apaf-1-me- diated pro-casp9 activation requires intrinsic casp9 protease activity. Wild type or mutant (C287S) pro-casp9 was incubated with wild type or Apaf-1-(1-559)...
Structure,2017,25(3):407 420.DOI: 10.1016/j.str.2016. 12.019. [13] JemmersonR,StaskusK,HigginsLA,etal.Intracellularleucine rich alpha 2 glycoprotein 1competeswithApaf 1forbindingcytochrome cinprotectingMCF 7breastcancercellsfromapoptosis[J].Apopto sis,2021,26(4):1 12.DOI:10.1007/s10495 020 ...
As a broad-spectrum and efficient triazole fungicide, difenoconazole is widely used, which not only pollutes the environment but also exerts toxic effects on non-target organisms. The spleen plays an important role in immune protection as an important secondary lymphoid organ in carp. In this study...
Caspase structure, proteolytic substrates, and function during apoptotic cell death Cell Death Differ 1999 6: 1028–1042 Article CAS Google Scholar Boldin MP, Goncharov TM, Goltsev YV, Wallach D . Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor...
Structure of Apaf-1 in the Auto-Inhibited Form ND ES SC ACKNOWLEDGEMENTS RIBBao, QingRiedl, Stefan JBao Q., Riedl S.J., Shi Y.: Structure of Apaf-1 in the auto-inhibited form: a critical role for ADP. Cell Cycle 2005; 4: 1001-1003...
the structure,distribution and expression of Apaf-1 and the expression of chemo-therapy drug resistance.%乳腺癌的新辅助化疗不但可以降低临床分期,提升保乳率,还可以判断化疗药物的敏感性,并指导术后化疗用药,已逐渐成为乳腺癌综合治疗的首选.但仍有少数乳腺癌患者不能从新辅助化疗中受益,预测乳腺癌新辅助治疗的...