Adaptor protein complex-4 (AP-4) deficiency causes a novel autosomal recessive cerebral palsy syndrome with microcephaly and intellectual disability. J Med Genet 2011; 48: 141-144.Moreno-De-Luca A, Helmers SL, Mao H et al. Adaptor protein complex-4 (AP-4) deficiency causes a novel ...
建议收到该AP-4 Complex Subunit Beta-1 (AP4B1) Antibody产品后,储存温度为-20°C。避免重复冻融 其他 Abbexa总部位于英国剑桥的剑桥科学园,是一家专业的全球抗体供应商和蛋白质供应商,致力于为生命科学、药物开发和生物技术领域的科学家和研究者提供最佳的客户体验和高质量的产品。产品涵盖一抗、二抗、蛋白质、...
英文名称:Assay kit for Canine AP 4 complex subunit 1 ELISAAssay kit for Canine AP 4 complex subunit 1 ELISA is available 8 times 来自 Bluegen elisas labs,中文名称:犬AP 4复合亚基检测试剂盒1犬ap4复合亚基ELISA试剂盒8个,产品货号:E08
Adaptor protein 4 (AP-4) is an ancient membrane trafficking complex, whose function has largely remained elusive. In humans, AP-4 deficiency causes a severe neurological disorder of unknown aetiology. We apply unbiased proteomic methods, including ‘Dynamic Organellar Maps’, to find proteins whose...
Characteristics of the AP-4 complex AP-4 mediates cargo export from the TGN AP-4 accessory proteins Mouse studies reveal a role for AP-4 in brain development and function AP-4-deficiency syndrome: hereditary spastic paraplegia caused by mutations in AP-4 Prospects for the treatment of AP-4-...
英文名称:Assay kit for Guinea pig AP 4 complex subunit 1 ELISAAssay kit for Guinea pig AP 4 complex subunit 1 ELISA is available 8 times 来自 Bluegen elisas labs,中文名称:豚鼠AP 4复合亚基检测试剂盒1豚鼠AP 4复合亚基ELISA试剂盒8,产
In this study, we developed a high-throughput screening assay to identify molecules that correct aberrant protein trafficking in adapter protein complex 4 (AP-4) deficiency, a rare but prototypical form of childhood-onset hereditary spastic paraplegia characterized by mislocalization of the autophagy ...
Taken together, these observations suggest a possible role for the AP-4 complex in sorting to lysosomes. However, the signals from all of these lysosomal membrane proteins interact better with μ2 and μ3A than with μ4 (Fig. 2, A and B). To gain insight into the potential function of ...
Here, we describe the signal-binding specificity and affinity of the medium subunit μ4 of the recently described adaptor protein complex AP-4. To elucidate the determinants of specificity, we screened a two-hybrid combinatorial peptide library using μ4 as a selector protein. Statistical analyses...
We recently demonstrated that adaptor protein complex-4 (AP-4) binds to transmembrane AMPA receptor regulatory proteins (TARPs), thereby mediating the selective trafficking of AMPA receptors to the somatodendritic domain; genetic disruption of AP-4 (AP-4β–/–), results in the mislocalization of...