Adaptor protein 4 (AP-4) is an ancient membrane trafficking complex, whose function has largely remained elusive. In humans, AP-4 deficiency causes a severe neurological disorder of unknown aetiology. We apply unbiased proteomic methods, including ‘Dynamic Organellar Maps’, to find proteins whose...
索斯兰美高项目学术主管Paul Segura寄语: I am delighted to witness the daily involvement of our students in their AP classes. They are getting familiar with US college type instructions by developing their critical thinking skills and analyzing mo...
在这一项评分标准中,三道写作题均使用了相同的标准。考生需要“Demonstrates sophistication of thought and/or develops a complex understanding of the rhetorical situation.”即能够表达有深度、有复杂性的想法。这里的“rhetorical situation”大家可以理解为表达的场合。也就...
模块尺寸50x26x9mm(高度可选),选用插件DIP-70封装,1WAN+4LAN/USB/Uart/GPIO/PCIE接口;是最完整的核心模块,通过PCIE接口可以扩展成双频率AP(有符合802.11ac标准的QCA9887大功率@26dBm 模块可直接用);如果悬空其中的PCIE接口,兼容性很强,MT7668、MT7628、MT7628+MT7612和QCA9531+AR9582双频有同样Pin定义的方案,...
这种成键方式常见于配位化合物/络合物(coordination compound/complex)中。 配位键 配位键与共价键的区别在于共价键是两个原子各提供一个电子形成电子对,配位键则是一个原子提供整对电子另一个原子接受。 3.绘制共价化合物的路易斯电子式 3.1 N-A=S法则 需要的价电子总数(N)-可用的价电子总数(A)=共用电子数...
Cambodia defends family relocations around the famous Angkor Wat temple complex March 4, 2024 Israel criticizes UN vote to list ruins near ancient Jericho as World Heritage Site in Palestine September 18, 2023 Venice and its lagoon again escape inclusion on UNESCO list of heritage sites in ...
In this study, we developed a high-throughput screening assay to identify molecules that correct aberrant protein trafficking in adapter protein complex 4 (AP-4) deficiency, a rare but prototypical form of childhood-onset hereditary spastic paraplegia characterized by mislocalization of the autophagy ...
2. 正文段展开思路:本文的分析可以按照上述的complex characterization的不同侧面来分段,具体如下: (1) 最初大部分居民对于the octopus walking out of the sea的态度是“stood back” 以及 “amazed”(line 10) , 此处表现除了大部分居民对于octopus的反应正如ordinary people一样,对于奇怪的事物表现出astounded以及...
Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. The DCX(TRUSS) complex specifically mediates the polyubiquitination and subsequent degradation of MYC. Also participates in the activation of NFKB1 in response to ligation of...
Simanshu DK, Savithri HS, Murthy MR: Crystal structures of Salmonella typhimurium propionate kinase and its complex with Ap4A: evidence for a novel Ap4A synthetic activity. Proteins 2008, 70 (4) : 1379–1388. View ArticleSimanshu DK, Savithri HS, Murthy MR: Crystal structures of Salmonella ...