Immunology Batf regulates previously unknown AP-1 target genes to control TH17 differentiation WASHINGTON UNIVERSITY IN ST. LOUIS Kenneth M. Murphy SchramlBarbara UrsulaActivator protein 1 (AP-1) transcription factors are dimers of Jun, Fos, musculoaponeurotic fibrosarcoma (MAF) and activating ...
Structure and transcriptional regulation of BKJ, a novel AP-1 target gene activated during jun- or fos-induced fibroblast transformation. Hartl M, Bister K. (1998). Structure and transcriptional regulation of BKJ, a novel AP-1 target gene activated during jun- or fos-induced fibroblast ... M...
This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromoso...
JUN is the putative transforming gene of avian sarcoma virus 17. It encodes a protein(Jun proto-oncogene, AP-1 transcription factor subunit) which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. JUN is intronles...
How can PD-L1's implication in cancer be used as a drug target? In certain tumors, high expression of PD-L1 serves as a stop-sign to inhibit the recognition of cancer cells by T-cells (PMID: 23087408). The interaction between PD-L1 and its receptors (PD1 and B7.1) is a mechanism ...
Activating transcription factor 6 (ATF6) is a transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N(9)-CCAC[GA]-3') and of ERSE ...
A luciferase assay using a stably integrated chromosomal AP-1 reporter construct (collagenase–luciferase) showed a similar decrease in gene expression when either Trim7 or RACO-1 were depleted with shRNA, consistent with Trim7 regulating the transcription of c-Jun/AP-1 target genes via RACO-1 ...
4 The diverse effects of AP-1 on cell death and survival probably arise from the combinatorial diversity of AP-1 dimers as well as activation of different groups of pro- or antiapoptotic target genes.1,2,5 Secretogranin II (SgII) is a putative AP-1-regulated gene.6–10 SgII is a ...
Reactive oxygen species (ROS) activate JNK, p38 and ERK mitogen-activated protein kinases (MAPK), which upregulate c-Jun and c-Fos expression at the transcriptional level. Expression of c-Jun, a target gene of Jun/AP-1, increases through JNK-induced transactivation. JNK, p38 and ERK ca...
ACLY serves as not only a target in oxygenated cells for suppression of lipid synthesis and histone acetylation, but also as a susceptible target in hypoxic cells to restore inhibition of glycolysis. In nonsmall cell lung carcinoma and hepatocellular carcinoma, ACLY is overexpressed compared with ...