To interrogate whether AP-1 or TGFß are sufficient to drive MRTF-mediated resistance, we used our NIH-3T3 model where overexpression of constitutively active MRTF (MRTF-N) in tandem with subthreshold Smoothened agonist (SAG) enhances Gli signaling12. 3T3 cells are a useful proxy for sensitive...
在AP-1和NF-κB的上游存在许多信号分子(激酶和磷酸酶),它们是潜在的治疗药物靶标。激酶JNK在调节c-jun(构成AP-1复合物(fos/c-jun)的亚单位之一)的磷酸化和随后的激活中起着关键作用。抑制JNK的化合物已经显示在炎症性疾病的动物模型中是有效的。参见Manning,A.M.and Davis,R.J.,Nature Rev.Drug Disc.,V...
浓度:400 ug/ml 库存:现货 点击咨询售前客服 点击咨询售后客服 mouseWB Small molecule agonist of mitochondrial fusion repairs mitochondrial dysfunction mouseWB Sci Adv Mitochondrial proteostasis stress in muscle drives a long-range protective response to alleviate dietary obesity independently of ATF4. ...
Cutting edge: the "death" adaptor CRADD/RAIDD targets BCL10 and suppresses agonist-induced cytokine expression in T lymphocytes. Authors - Lin Qing Q KO Validated View Article human, mouse WB J Biol Chem The Adaptor CRADD/RAIDD Controls Activation of Endothelial Cells by Proinflammatory Stimuli. ...
Our observations thereby provide new insights into the mechanisms by which ERs act at alternate response elements, and suggest a mechanism by which tamoxifen exerts its action as a tissue-selective agonist.doi:10.1186/1478-1336-2-3Linda Bj?rnstr?m...
We tracked activated STING (phosphorylated at S366; hereafter pSTING)) (ref.17) along its intracellular trafficking route by high-resolution confocal and Airyscan microscopy in HeLa cells. Extending previous findings20,21, after stimulation with the small-molecule agonist diABZI-C3 (hereafter, diABZI...
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4B). More importantly, the inhibitory effect on AP-1 activation by NRBP appeared to be specific, since overexpression of NRBP completely failed to interfere with NFκB activation induced by PMA or a natural agonist TNF in 293T cells (Fig. 4C and D). Taken together, these results demonstrate...
PPARα agonist WY-14,643 enhances ethanol metabolism in mice: role of catalase. Authors - Xue Chen KO Validated View Article See more citations Reviews Add a review The reviews below have been submitted by verified Proteintech customers who received an incentive for providing their feedback. FH...
品牌默克密理博/Millipore 单件重量1kg 货期45天 单位:盒包装:盒库存:0 数量:盒+-1盒起订,增量1盒 累计成交0笔0条评价 选择其它规格 商品名 贝雷猫货号 原厂编号 品牌 商品规格 单位 货期 价格 库存 购买 RH156048 5.31621.0001 默克密理博/Millipore ...