Agonist主要通过模拟特定的neurotransmitters与receptor结合发生作用(见图1)。前文提到过neurotransmitter和它所对应的receptor就像是原配钥匙与锁的关系,agonist相当于仿制钥匙,形状和neurotransmitter非常相似,也可以打开receptor这把“锁”从而像neurotransmitter一样发挥作用。比如,Parkinson’s disease(帕金森,一种退行性神经疾病...
降血脂药可以是ACAT抑制剂,例如如以下文献中披露的物质Drugsof the Future,24,9-15(1999),(Avasimibe(阿伐麦布));“The ACAT inhibitor,Cl-1011is effective in the prevention and regression of aortic fatty streak area inhamsters”,Nicolosi等人.,Atherosclerosis(Shannon,Irel).137(1),77-85(1998);“The...
Cat No.14676-1-AP 浓度:400 ug/ml 库存:现货 点击咨询售前客服 点击咨询售后客服 mouseWB Small molecule agonist of mitochondrial fusion repairs mitochondrial dysfunction mouseWB Sci Adv Mitochondrial proteostasis stress in muscle drives a long-range protective response to alleviate dietary obesity independen...
Applications:Western Blot Primary Antibody Dilution:1:5000 Cell Tissue Type:prostate/ RWPE-1 CSNK2A1 Antibody Western Blot validation (1:5000 dilution) in prostate/ RWPE-1 (Cat no:10992-1-AP)
JunD/AP-1, but not TGFß, is sufficient to drive nMRTF To interrogate whether AP-1 or TGFß are sufficient to drive MRTF-mediated resistance, we used our NIH-3T3 model where overexpression of constitutively active MRTF (MRTF-N) in tandem with subthreshold Smoothened agonist (SAG) enhances...
MSDS ¥2200/100 μL Cat No.55156-1-AP 浓度:387 μg/ml 库存:现货 点击咨询售前客服 点击咨询售后客服 mouse,humanWB mouseWB Free Radic Biol Med PPARα agonist WY-14,643 enhances ethanol metabolism in mice: role of catalase. mouseWB ...
Lin28 enhances de novo fatty acid synthesis to promote cancer progression via SREBP-1. Authors - Yang Zhang View Article mouse WB Free Radic Biol Med PPARα agonist WY-14,643 enhances ethanol metabolism in mice: role of catalase. Authors - Xue Chen KO Validated View Article See more citation...
MAPK/AP-1 acti- vation mediates TLR2 agonist-induced SPLUNC1 expression in human lung epithelial cells. Mol Immunol 2011; 49: 415-422.J. Thaikoottathil and H. W. Chu, "MAPK/AP-1 activation medi- ates TLR2 agonist-induced SPLUNC1 expression in human lung epithelial cells," Molecular ...
Liraglutide – GLP-1 Agonist Functionality Liraglutide is a once-daily injectable medication that mimics the GLP-1 hormone effect. It works by stimulating insulin secretion when glucose levels are high, helping the body manage blood sugar more effectively. Additionally, liraglutide slows down gastric ...
Propane-2-sulfonic acid octadec-9-enyl-amide, a novel PPARα/γ dual agonist, attenuates molecular pathological alterations in learning memory in AD mice. Li Y, Zhang Y, Wang Q, Wu C, Du G, Zeng Y, Song Z, Jiang X, Jiang X, Zhuo R, Li J Neurological research 2024 May;46(5):41...