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2. The clinical diagnosis status was used as the case status phenotype for this study, which was largely consistent with Consortium to Establish a Registry for Alzheimer’s Disease (CERAD) score (Mirra et al., 1991), a semiquantitative measure of neuritic plaques where a neuropathologic ...
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J. Biol. Chem. 254, 4739–4744 (1979). Article CAS PubMed Google Scholar Burley, S. K. et al. RCSB protein data bank: powerful new tools for exploring 3D structures of biological macromolecules for basic and applied research and education in fundamental biology, biomedicine, biotechnology, ...
In the heat map, blue indicates low expression and red indicates high expression. The black line in the topological graph indicates the interaction between genes, and the thicker the line is, the deeper the relationship is; the ellipse represents genes, and the color represents the score of ...
Cells were plated subconfluently in 96-well plates, then serum starved and treated with the following inhibitors: vismodegib (GDC-0449; SelleckChem), CCG-1423 (Cayman Chemicals), T-5224 (SelleckChem), SR11302 (Cayman Chemicals), SB431542 (SelleckChem), SP600-125 (SelleckChem), JNK-IN-8 ...
(n = 4 mice per group). Expression values are normalizedzscores.d, GSEA of the indicated signatures. FDR, color intensity of circles; NES, circle diameter. Blue and red indicate the group in which the signature was positively enriched; NES, normalized enrichment score; FDR, false ...
protein has a solubility score of 0.555. Solubility-scaled proteins using the Protein-sol server that have a score greater than 0.45 indicate a higher solubility than the average solubleE. coliprotein from the experimental solubility dataset [45]; therefore, our designed protein has a high ...
The negative log10 of the corrected p-value corresponded to a protein’s movement (M) score. Next, the reproducibility of observed delta profiles across replicates was determined as the Pearson correlation (Δmap (Con_1-AP4B1_1) vs. Δmap (Con_2-AP4B1_2); and Δmap (Con_1-AP4E1_1...