Mechanism of action of antithymocyte globulin in the treatment of aplastic anaemia: In vitro evidence for the presence of immunosuppressive mechanism. Br J Haematol 1997; 96: 80.Termura M, Kobayashi S, Iwabe K, et al. Mechanism of action of antithymocyte globulin in the treatment of aplastic...
Keywords: infectious risks associated with anti-thymocyte globulin (ATG, thymoglobulin); mechanism of action - anti-thymocyte globulin (ATG), polyclonal antibody inducing dose-dependent depletion of T cells; duration of effect - profound CD3 lymphopenia, lasting 1 year; impact on laboratory monitoring...
Lopez M, Clarkson MR, Albin M, Sayegh MH, Najafian N: A novel mechanism of action for anti-thymocyte globulin: induction of CD4+CD25+Foxp3+ regulatory T cells. J Am Soc Nephrol. 2006, 17 (10): 2844-2853. 10.1681/ASN.2006050422. Article PubMed CAS Google Scholar Feng X, Kajigaya...
Mechanism Of Action ATGAM is composed of antibodies that bind a wide variety of proteins on the surface of lymphocytes. In addition, ATGAM binds to granulocytes, platelets, bone marrow cells, and other cell types. The mechanism of ATGAM-induced immunosuppression has not been determined. Published...
Mechanism of action of antithymocyte globulin in the treatment of aplastic anaemia: in vitro evidence for the presence of immunosuppressive mechanism. Antithymocyte globulin (ATG) is one of the effective drugs used in the treatment of aplastic anaemia (AA). Although it has been speculated that the...
Advances in the understanding of the multifaceted mechanism of action will guide research into new therapeutic areas and future applications.doi:10.2165/11315940-000000000-00000GaberDepartmentA.DepartmentOsamaDepartmentMonacoDepartmentAnthonyDepartmentP.
One of the most widely used T-cell depleting agents in clinical transplantation is polyclonal rabbit anti-human thymocyte globulin (Thymoglobulin), for which mechanisms of action have been reviewed [7], [8], [9]. For laboratory studies of Thymoglobulin, a surrogate rabbit anti-murine thymocyte ...
Anti-thymocyte globulin (ATG) is an established approach to decrease chronic GVHD (cGVHD), yet the exact mechanism is uncertain. To better understand the mechanism of action of ATG in preventing cGVHD, we evaluated the day 100 immune reconstitution of known cGVHD cellular biomarkers using patients...
Antithymocyte globulin (ATG) is an effective treatment in patients with severe aplastic anemia (SAA). Its mechanism of action remains unclear, although it has been assumed to be immunosuppressive. However, ATG has also been shown by several laboratories to be immunostimulatory. Recently, interleukin...
Despite the proven efficacy of ATG in these areas, its mechanism of action is not known. Profound T-cell lymphopenia observed in vivo with ATG treatment is supposed to contribute to its therapeutic effect. We have previously shown that apoptosis is one of the mechanisms responsible for ATG-...