L. ZenderS. HuetkerM. P. MannsF. KuehnelS. KubickaElsevier B.V.Journal of HepatologyZender et al., " Small interfering RNA (SIRNA) and Antisense oligonucleotides (ASO) for Reversion of chemotherapy resistance in hepatoma cells, " Journal of Hepatology, vol. 38, Suppl. 02, (Apr. 1, ...
Antisense oligonucleotides, like siRNA, allow for a targeted approach to MDR1 gene-silencing and should decrease non-specific cytotoxic effects, which are typical of small molecule inhibitors. Antisense oligonucleotides have been developed against MDR1 and other MDR-related transporters (i.e., MRP1,...
Therefore we are interested to improve the proliferation of primary myoblasts of DMD patients by a reduction in p21 using either antisense oligonucleotides (ASO) or short interfering RNAs (siRNA). After transient transfection of myoblasts in cell culture proliferation was analyzed using a 5-bromo-2...
For knockdown experiments, cells were tran- siently transfected with LNAs antisense oligonucleotides (Exiqon) using Lipo- fectamine 2000 (Invitrogen, Carlsbad, CA) in the light of the manufacturer's protocol. The LNAs antisense oligonucleotides and siRNA sequences are listed in Supplementary Table ...
Successful skipping of abnormal pseudoexon by antisense oligonucleotides in vitro for a patient with beta-propeller protein-associated neurodegeneration Article Open access 18 March 2024 Dose-dependent reduction of somatic expansions but not Htt aggregates by di-valent siRNA-mediated silencing of MSH3 ...
Methods of using these oligonucleotides for inh... JG Karras - US 被引量: 47发表: 2000年 Myeloid cells as a target for oligonucleotide therapeutics: turning obstacles into opportunities Conjugation of a STAT3siRNA or decoy STAT3 inhibitors to synthetic Toll-like Receptor 9 (TLR9) agonists, CpG ...
Zhang Q,Zhang ZF,Rao JY,et al.Treatment with siRNA and antisense oligonucleotides targeted to HIF-1 alpha induced apoptosis in human tongue squamous cell carcinomas. International Journal of Cancer . 2004Zhang Q,Zhang ZF,Rao JY,et al.Treatment with siRNA and antisense oligonucleotides targeted to...
2. Rinaldi, Carlo, and Matthew J. A. Wood. “Antisense Oligonucleotides: The next Frontier for Treatment of Neurological Disorders.” Nature News, Nature Publishing Group, 1 Dec. 2017. Image Courtesy: 1. “Rna interference plos” By Marjori A. Matzke, Antonius J. M. Matzke – Matzke...
mRNA, messenger RNA; miRNA, microRNA; RISC, RNA-induced silencing complex; siRNA, short interfering RNA. Similarly to steric-blocking mRNA binding, some oligonucleotides are also capable of binding in triplex mode to certain specific DNA sequences and inhibiting transcription in the nucleus, leading...
Sepp-Lorenzino L, Ruddy M: Challenges and opportunities for local and systemic delivery of siRNA and antisense oligonucleotides. Clin Pharmacol Ther 2008, 84: 628–632.Sepp-Lorenzino L, Ruddy M. Challenges and opportunities for local and systemic delivery of siRNA and antisense oligonucleotides. ...