Yahr, M DKorczyn AD (1979) Psychiatric side ef- fects of antiparkinson drugs. In: Nandy K (ed) Geriatric Psychophar- macology. Elsevier, pp 157-170Korczyn AD (1979). Psychiatric side effects of antiparkinson drugs. In: Nandy K ed. Geriatric Psychopharmacology. Elsevier, pp. 157-1702....
Rummel-Kluge, C,Komossa, K,Schwarz, S(2012).Second-generation antipsychotic drugs and extrapyramidal side effects: a systematic review and metaanalysis of head-to-head comparisons.Schizophr Bull,38,167-77. Schneider, LS,Tariot, PN,Dagerman, KS(2006).Effectiveness of atypical antipsychotic drugs...
10.11 Piperidine-Based Antiparkinsonian drugs Trihexyphenidyl (2.1.1) is classified as an antiparkinsonian agent. It is a centrally acting muscarinic antagonist used as an antispasmodic for treatment of parkinsonian disorders or drug-induced extrapyramidal movement disorders. It can cause side effects su...
Intranasal administration is a non-invasive and effective way for the delivery of drugs to brain that circumvents the blood brain barrier (BBB). Taking thi... J Ali,A Ahuja,S Baboota,... - 《Current Nanoscience》 被引量: 23发表: 2012年 Novel surface modified polymer–lipid hybrid nanopar...
However, some antiepileptic drugs, such as carbamazepine and phenobarbital, decrease safinamide plasma concentration and shorten the half-life [19,20,21]. On the other hand, safinamide does not affect the plasma concentrations of these drugs. Safinamide also does not affect oral tyramine, which is...
XPro1595 targets tumor necrosis factor (TNF), a critical inflammatory signaling molecule, and is specific to the soluble form of TNF. This specificity would avoid compromising immunity to infections, a known side effect of existing anti-TNF drugs used to treat disorders such as rheumatoid ...
The success of conventional chemotherapies is also dismal, and patients succumb to its debilitating effects. Novel treatment strategies are thus required for the management of this lethal disease.3 The repurposing of existing drugs is considered as an effective drug developmental strategy to counteract ...
Its anti-inflammatory, antioxidant, and antitumor activities improve the efficacy of conventional chemotherapeutic drugs while reducing side effects. Curcumin may reverse cancer progression through the inhibition of IL-6R/STAT3. It also sensitizes cancer to antitumor and antimetastatic effects by suppressing...
Current evidence suggests a role of neuroinflammation in the pathogenesis of Parkinson's disease (PD) and in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model of basal ganglia injury. Reportedly, nonsteroidal anti-inflammatory drugs (NSAIDs)
Keywords:Non-steroidalanti-inflammatorydrugs;Alzheimer'sdisease;Parkinson's disease;cyclooxygenase;neuroinflammation 1.Introduction AccordingtotheUnitedStatesCentersforDiseaseControlandPrevention,theaverageAmerican lifespanhasincreasedfrom73.7years(1980)to77.9years(2007)[1].Agingisassociatedwith increasedriskofneurologic...