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According to the researchers, subthalamic nucleus stimulation may have a direct effect in lessening the side effects of Parkinson medication such as dyskinesia. They noted that short latency afferent inhibition is reduced in the stimulator-off condition and restored by subthalamic nucleus stimulation....
,... - 《Cns Drugs》 被引量: 48发表: 2009年 Subcutaneous infusions of apomorphine: a reappraisal of its therapeutic efficacy in advanced Parkinson’s disease: Expert Review of Neurotherapeutics: Vol ... Levodopa is still considered the most potent trigger for DDS in Parkinson's disease, but ...
one of the biggest future challenges for imaging techniques applied to PD is to integrate their results to identify the mechanisms that might be targeted with drugs and other
effects, and ways to increase the efficacy of these treatments. There are a number of biodegradable, non-invasive Parkinson's disease treatment approaches that can carry drugs over the blood-brain barrier and deliver them to the site of action while accounting for side effects. Ability to ...
[17], none of them effectively halt the progression of PD. The few symptomatic treatments currently available, are appropriate for only a limited number of patients. Moreover, side-effects, short-life span, and permeability issues are the major problems for use of these drugs against PD. ...
• Non-ergot drugs • Selective D2-R agonists • Monotherapy for early PD, combined with lododopa/carbidopa in latter stages of PD (reduce the problems of “wear-off” and “on/off”) • Side effects: similar to the other DA agonists ...
depletions, and to investigate the promotive effects of experimental and clinical approaches which are relevant for the treatment of Parkinson's disease. These... RKW Schwarting,JP Huston - 《Progress in Neurobiology》 被引量: 1107发表: 1996年 The neurotoxicity of amphetamines: Bridging drugs of ...
they exhibit significant side effects (such as memory disturbances or somnolence), which makes them unusable in most elderly parkinsonian patients. Although dopaminergic therapy has largely supplanted the use of anticholinergic drugs, they are still used in clinical practice, particularly in younger PD...
However, the currently-used drugs employing these methods have many adverse reactions. For instance, DA agonists and levodopa induce nausea, daytime somnolence, and edema [1]. DA agonists are also commonly associated with hallucinations [7] and the long-term use of levodopa can result in motor...