Antibiotics fall into two broad categories; onethat inhibits bacterial growth (bacteriostatic), or ones that kill bacteria outright (bactericidal). As well, antibiotic protection is dependent on their individual compositions. Some antibiotics are only valued for one particular use. Others might be effec...
The U.K.’s world-first subscription model for antimicrobials is to be expanded following a successful pilot scheme in which companies are being paid a fixed annual fee for their drugs, regardless of the volume dispensed. Read More EU’s largest pharma reform in 20+ years advances, despite ...
Drugs 63(15):1579–1596 Article CAS PubMed Google Scholar Granata M, Skarmoutsou E, Gangemi P, Mazzarino MC, D’Amico F (2019) S100A7, Jab1, and p27(kip1) expression in psoriasis and S100A7 CRISPR-activated human keratinocyte cell line. J Cell Biochem 120(3):3384–3392 Article ...
The broad-spectrum antimicrobial activity of many amphibian AMPs continues to fuel the perception that they are promising lead compounds for the development of new antibiotics3,18,37,38. The present evidence however, implies that pharmacological studies seeking to optimize the therapeutic potential of ...
Our interviewees did not explicitly distinguish between drugs with a public goods character and for which there is insufficient demand, such as antibiotics, and others. On the contrary, they argued that potential market size is key to whether GGFs would invest in a given innovative drug (...
(Rustamova et al.2020). To deal with these problems medicinal plants are continuously being used in large quantities for producing desired drugs which, however, leads to a decrease in their population. Therefore, alternatives such as endophytes (bacteria or fungi) can be employed for this ...
Similarly, when combining CP-containing cryogels with other drugs or proteins to be released from the cryogels, possible interactions or damage resulting from the presence of hydrogen peroxide might need to be taken into consideration. Finally, the needle-injectable antibacterial cryogels reported here...
Provides the full microbiological taxonomy and extensive info on all antimicrobial drugs Applies all recent CLSI and EUCAST clinical and veterinary breakpoints for MICs, disk zones and ECOFFs Corrects for duplicate isolates, calculates and predicts AMR per antimicrobial class Integrates with WHONET, ATC,...
The rising incidence of antimicrobial resistance continues to project a global healthcare concern. The spread of drug-resistant pathogens and indiscriminate use of the existing antibiotics has a profound effect on the economy of developing and under-deve
persistence is a concept seen in bacteria treated with bactericidal drugs, where rare (>0.1% of the population for most commonly used antibiotics42), metabolically quiescent cells survive by not metabolizing the cidal drug. Antifungal persistence was associated with biofilms in one study, but it has...