nonsusceptibility to at least one agent in all but two or fewer antimicrobial categories)E. coli, we examined the compositional profiles of ARGs in each genome. Among the 492 genomes containing at least 2 ARGs, we identified 406 combinations of distinct ARGs (Supplementary Data7). More than...
The direct combination of experimental and ML techniques in a closed-loop approach has also benefited the development of new AMPs. Starting from a template with known antimicrobial activity and a series of homologous sequences, it was possible to train a generalized linear model to create new AMPs...
The Actinobacteria phylum is one of the oldest bacterial phyla that have a significant role in medicine and biotechnology. There are a lot of genera in this phylum that are causing various types of infections in humans, animals, and plants. As well as antimicrobial agents that are used in med...
The penicillins have a unique structure, a β-lactam ring, that is responsible for their antibacterial activity. The β-lactam ring interacts with proteins in the bacterial cell responsible for the final step in the assembly of thecell wall. ...
Glycopeptide antimicrobials are a class of naturally occurring or semi-synthetic glycosylated products that have shown antibacterial activity against gram-positive organisms by inhibiting cell-wall synthesis. In most cases, these drugs are prepared in dr
Resistance of gram-negative bacteria to current antibacterial agents and approaches to resolve it 2020, Molecules Antimicrobial stewardship: Fighting antimicrobial resistance and protecting global public health 2020, Infection and Drug Resistance Considerations and Caveats in Combating ESKAPE Pathogens against No...
Introduction Quaternary ammonium compounds (QACs) intended for preservative and antimicrobial applications are present in a wide variety of products, resulting in potential exposures in many settings [1,2]. For example, QACs can be found in personal care products, ophthalmic medications, skin antisept...
Incidence of allergic reactions associated with antibacterial use in a large, managed care organisation. Drug Saf. 2007;30(8):705-713.PubMedGoogle ScholarCrossref 29. Meropol SB, Localio AR, Metlay JP. Risks and benefits associated with antibiotic use for acute respiratory infections: a ...
H. Antibacterial activity of eravacycline (TP-434), a novel fluorocycline, against hospital and community pathogens. Antimicrob. Agents Chemother. 57, 5548–5558 (2013). Article CAS PubMed PubMed Central Google Scholar Macone, A. B. et al. In vitro and in vivo antibacterial activities of...
as the emergence of antibiotic resistance renders existing antibacterial drugs less efficient and thus necessitates a constant race to discover new ways to fight microbial infections73. Out of the 6 ARGs discovered in this work, we found that 5 homologs inS. entericaalso conferred resistance to an...