previously exposed to the antigen, by in vitro expansion of antigen-specific T cells; isolating a nucleic acid encoding a T cell receptor having the specificity of the T cell receptor of the single antigen-reactive T cell; and introducing the nucleic acid into a lymphoid cell.SELECTED DRAWING:...
Detection of more than 1,000 different T-cell specificities in parallel facilitates identification of cancer and autoimmune antigens. Identification of the peptides recognized by individual T cells is important for understanding and treating immune-relat
Cell Cultures. T cells from lymph nodes draining the sites of immunization were prepared as previously described (23) by passage over nylon-wool columns and cultured in Click's medium with 100 #g/ml of antigen and irradiated (2,000 rad) spleen cells as a source of antigen- presenting cells...
It is commonly understood that T cells are activated via trans interactions between antigen-specific T-cell receptors (TCRs) and antigenic peptides presented on major histocompatibility complex (MHC) molecules on antigen-presenting cells. By analysing a large number of T cells at the single-cell ...
Antigen-specific cytotoxicity and cell number of adoptively transferred T cells are efficiently maintained in vivo byre-stimulation with an antigen:Interleukin... BY Kang,YS Lim,WC Su,... - 《International Journal of Cancer》 被引量: 53发表: 1999年 Dendritic Cells Strongly Boost the Antitumor ...
Non small cell lung cancers (NSCLC) express cancer/testis antigens (CTA) genes and MAGE-A expression correlates with poor prognosis in squamous cell carcinomas. We addressed cytotoxic T lymphocytes (CTL) responses to HLA class I restricted CTA epitopes in TIL from NSCLC in an unselected group ...
Cutting Edge: Control of CD8~+ T Cell Activation by CD4~+CD25~+ Immunoregulatory Cells CD4~+CD25~+ regulatory T cells inhibit organ-specific autoim- mune diseases induced by CD4~+CD25~- T cells and are potent suppressors of CD4~+CD25~- T cell... Ciriaco,A.Piccirillo,Ethan,... - 《...
Studies in B cell-deficient mice generated by continuous injection of anti-mu antibodies (muSM) showed that T cell priming in lymph nodes was dependent on antigen presentation by B cells. This concept has recently become controversial since a wide range,
Here, we present a computational framework for unbiased combinatorial polyfunctionality analysis of antigen-specific T-cell subsets (COMPASS). COMPASS uses a Bayesian hierarchical framework to model all observed cell subsets and select those ... L Lin,G Finak,K Ushey,... - 《Nature Biotechnology...
Development of a Wilms' tumor antigen-specific T-cell receptor for clinical trials: engineered patient's T cells can eliminate autologous leukemia blasts in... SA Xue,L Gao,S Thomas,... - 《Haematologica》 被引量: 133发表: 2010年 In search of the 'missing self': MHC molecules and NK ...