✌🏻 Antigen-Specific Antibody Design and Optimization with Diffusion-Based Generative Models for Protein Structures (NeurIPS 2022) - CuiDachao/diffab
The AbBERT is the pre-trained antibody model. Its `soft' prediction will be fed into the sequence GNN H seq, after encoding and generating the updated sequence, structure GNN H str encodes the updated graph and then predict the structures. The sequence and structure prediction iteratively ...
Combinatorial antibody libraries displayed on filamentous phage have reached a size of approximately 10members, theoretically with different specificities. Design of large naive or synthetic antibody libraries also underlines the necessity to use new approaches for phage selection to find a single (or ...
(Humira),totreatrheumatoidarthritis5.Thedis-advantageo thismethodisthatphagesdonotdisplaynaturallypairedheavyandlightantibodychains.Single-cellPCR-basedantibodycloningavoidsthisproblem6,7.Formanyyears,theprincipalchallengeinusingthistechniquewasthedesigno primersthatcapturethevariableantibodyrepertoire8–11.Thus,...
The association of autoimmune diseases with particular allellic products of the class-II major histocompatibility complex (MHCII) region implicates the presentation of the offending self-antigens to T cells. Because antigen-presenting cells are tolerogen
The data show that autoimmune responses characterized by strong T-cell proliferation and high titers of antibody to self hsp60 are induced only by concurrent immunization with mouse and chlamydial hsp60. Immunization with mouse hsp60 alone induced lymphocytes that secreted high levels of interleukin-...
(OKT3 antibody or anti-CD3/CD28 microbeads) or K562 artificial antigen-presenting cells (aAPCs) engineered to express the cognate antigen and co-stimulatory factors CD80, CD83 and CD137L (4-1BBL) (Supplementary Fig.9a). SP8s generated through activation of ATO−DP precursors through CD3 ...
Full size image Lung and serum antibody responses differ between CLH001 and PBK001 vaccine groups post challenge Fig. 7:Bpm-specific serum and lung IgG and IgA are the predominant responses in PBK001-vaccinated mice during infection whereas IgM is a major response in CLH001. ...
Then the immunogen was used to immunise New Zealand rabbits to produce the polyclonal antibody. The obtained antibody simultaneously cross-reacted with six penicillins (amoxicillin, penicillin G, ampicillin, penicillin V, carbencillin and sulbenicillin) and four tetracyclines (tetracycline, ...
This sophisticated antibody binds sites... T Xavier,JC Le - 《Drug Design Development & Therapy》 被引量: 12发表: 2016年 Targeted desialylation and cytolysis of tumour cells by fusing a sialidase to a bispecific T-cell engager Bispecific T-cell engagers (BiTEs) bring together tumour cells ...