The present invention provides compositions and methods for treating or preventing antibody mediated graft rejection and blood typing. Inventors: Holgersson, Jan (Vastra Frolunda, SE) Liu, Jining (Huddinge, SE) Lindberg, Linda (Sollentuna, SE) Grufman, Per (Huddinge, SE) Application...
The present invention provides an isolated monoclonal antibody, or an antigen-binding portion thereof, specifically binding to CD40. The present invention further provides a pharmaceutical composition comprising the antibody, or the antigen-binding portion thereof, as well as a treatment method using the...
Anti-acetylcholine receptor antibody specificities in serum and in thymic culture supernatants from myasthenia gravis patients. Neurology 38: 1784–1788. Article CAS Google Scholar Hesselmans L, Jennekens F, van den Oord C, Veldman H, and Vincent A (1993). Development of innervation of skeletal...
aRabbit polyclonal IgGs raised against four PvTRAgs (colour coded as Blue for -SP and magenta +SP) were used to study the localisation of the proteins inP. vivaxisolates. A rat antibody against PkMSP1–19was used as a merozoite surface marker for co-localisation studies. The first column i...
(1587) demonstrated that lymphocyte-enriched human peripheral blood cells failed to lyse antibody-coated chicken erythrocytes (CRBC) in the absence of C but were capable of exhibiting strong cytotoxicity when purified C components were added to such sensitized CRBC preparations. However, this required ...
26,27,28,29 SARS-CoV-2-specific T cell responses following infection or vaccination are often detectable earlier than antibody responses. Rapid cellular responses correlate with reduced disease severity following infection, and the S-specific T cell responses induced by vaccination with the S-protein...
Traditionally, alloimmunization to transfused blood products has focused exclusively on recipient antibodies recognizing donor alloantigens present on the cell surface. Accordingly, the immunologic sequelae of alloimmunization have been antibody mediated effects (ie, hemolytic transfusion reactions, platelet re...
The neutralizing antibody titers for blood samples collected on day 57 after vaccination were determined by PRNT. BHK-21 cells were seeded in 12-well plates, and twofold serial dilutions of serum samples were mixed with an equal volume of VACV Tian Tan strain containing ~100 PFU of virus per...
After aspiration, cells were gently pipetted to resuspend the pellet and 50 µL of pre-prepared antibody cocktails added to the residual liquid (1 min, RT, in the dark). FACS Buffer (50 µL) was added to unstained cells. Following AB labeling, cells were washed once by the ...
Matching donor and recipient blood groups based on red blood cell (RBC) surface ABO glycans and antibodies in plasma is crucial to avoid potentially fatal reactions during transfusions. Enzymatic conversion of RBC glycans to the universal group O is an attractive solution to simplify blood logistics...