Antigen specificity 翻译结果3复制译文编辑译文朗读译文返回顶部 Antigen specificity of 翻译结果4复制译文编辑译文朗读译文返回顶部 Antigen of idiosyncrasy 翻译结果5复制译文编辑译文朗读译文返回顶部 Antigen specificity 相关内容 ahave taken up vegetable gardening for the first time 正在翻译,请等待... ...
Optimization of therapeutic antibodies by predicting antigen specificity from antibody sequence via deep learning Abstract 治疗性抗体的优化是费时和消耗资源的,这主要是因为针对在哺乳动物中表达的全长抗体进行筛选是低通量的(大约103个变体),这通常导致数量很少的先导物。在这里,我们展示了通过深度学习从大量不同的...
the amino acid sequence prediction model being obtained by training data obtained by performing mask processing on some of sample amino acid word representations in sample data; and, on the basis of the amino acid sequence representation, determining the antigen specificity of the cellular receptor....
Fig. 1 | Implementing deep learning to predict antibody target specificity Fig2开始是具体的过程,对突变全局景观基于序列的分析,抗体的CDRH3序列(可变重链互补决定区)是决定其抗原特异性的关键因素,作者利用CRISPR-Cas9介导的同源突变(Homology-Directed Mutagenesis, HDM)技术,对表达曲妥珠单抗突变体(无法与HER2结合)...
Supplementary Figure 1 Binding capacity of DNA-barcoded MHC multimers and recovery of antigen specificity (a, b) Fluorescent-based determination of the binding capacity of DNA-barcoded MHC multimers (+barcode) compared to fluorescent labeled MHC multimers (-barcode). DNA-barcoded MHC multimer reage...
Germinal centre B cells: antigen specificity and changes in heavy chain class expression Germinal centres are histologically defined aggregates of blast cells that occur in B-cell areas of lymphoid tissues after antigenic stimulation. They are believed to be associated with the development of B-cell...
Share on Facebook spe·cies-spe·cif·ic an·ti·gen antigenic components in the tissues and fluids of members of a species of animal, by means of which various species may be immunologically distinguished; for example, serum albumin of horses is immunologically different from that of man, dog...
An antigen/antibody specificity exchanger is disclosed. It comprises: A) an amino-acid sequence corresponding to an amino-acid sequence of an antibody which specifically binds to a certain antigen, including hapten, B) linked by a link to C) an amino-acid sequence to which a certain antibody...
VDJmatch: a software for database-guided prediction of T-cell receptor antigen specificity VDJmatch is a command-line tool designed for matching T-cell receptor (TCR) repertoires against a database of TCR sequences with known antigen specificity. VDJmatch implements an API for interacting and que...
This maintenance of receptor function and specificity upon insertion of the Cbeta0 peptide cassette signifies a remarkable adaptability for the TCR beta-chain, and our findings open the possibility that this splice isoform may function in vivo. 展开 ...