The main goal of antigen-specific immunotherapy (ASI) in autoimmune and rheumatic diseases is to reprogramme or remove autoreactive cells and/or induce immune tolerance to self-antigens. Current therapies in these diseases either treat symptoms or slow down disease progression but are not yet ...
More than 25% of the population in industrialized countries suffers from immunoglobulin-E-mediated allergies. The antigen-specific immunotherapy that is in use at present involves the administration of allergen extracts to patients with the aim to cure a
C. et al. Epitope-specific immunotherapy of rheumatoid arthritis: clinical responsiveness occurs with immune deviation and relies on the expression of a cluster of molecules associated with T cell tolerance in a double-blind, placebo-controlled, pilot phase II trial. Arthritis Rheum. 60, 3207–...
pneumoniae bacteria, thereby producing antigen-specific antibodies. 然后利用该柱纯化肺炎链球菌的粗抗体,从而产生抗原特异性的抗体。 ceshi868.com 6. Evaluation of effectiveness of antigen specific immunotherapy for patients with allergic rhinitis 抗原特异性免疫治疗对过敏性鼻炎的疗效评价 www.ilib.cn 7. Long...
CD40–B cells overcome current obstacles, such as the difficulty of isolation, generation, and long-term expansion observed with other APCs. Therefore, they are an excellent source of professional APCs for immune assessment, antigen discovery, and antigen-specific immunotherapy....
摘要: Antigen-specific cancer immunotherapy targeting minimal residual disease emerges as a novel treatment modality in multiple myeloma. Two candidate target antigens were identified: cancer/testis (CT) antigen NY-ESO-1 and BCMA, a plasma-cell membrane receptor....
The primary objective of the trial (EudraCT No.: 2014-003520-44) is to evaluate safety and feasibility of active immunotherapy with antigen-loaded autologous DCs. The secondary objectives are to assess DC vaccination-induced T cell responses against WT1 and PRAME and to evaluate the clinical outco...
Explore tumor antigen-derived peptides for cancer immunotherapy, vaccine development, and antigen targeting.
Prostate-specific membrane antigen (PSMA) is expressed at high levels on malignant prostate cells and is likely an important therapeutic target for the treatment of prostate carcinoma. Current immunotherapy approaches to target PSMA include peptide, cell, vector or DNA-based vaccines as well as passiv...
The T cells used for adoptive immunotherapy can be generated either by expansion of antigen-specific T cells or redirection of T cells through genetic engineering (Park, Rosenberg et al. 2011). Transfer of viral antigen specific T cells is a well-established procedure used for the treatment of...