This chapter discusses the structure of antibodies and their specific recognition of antigens, the binding energetics of antibody-antigen interactions, the structural basis of the antibody maturation process, and limitations to antibody affinity and specificity for antigens. Antibodies may be regarded as...
IMMUNE FUNCTION AND ANTIBODY STRUCTURE CAROLYN S. FELDKAMP, JOHN L. CAREY, in Immunoassay, 1996 3.1. Antigen-Antibody Interaction Most antigen-antibody complexes have the characteristics of other well-studied protein-protein interactions. The free energy of binding is a function of the amount of sur...
The crystal structure of the complex of the anti-lysozyme HyHEL-10 Fab and hen egg white lysozyme has been determined to a nominal resolution of 3.0 A. The... DR Davies,S Sheriff,EA Padlan - 《Journal of Biological Chemistry》 被引量: 1531发表: 1988年 Structure of an antibody-lysozyme...
Peptide antigenicity against the pre-S2 region of the hepatitis B virus surface antigen was studied using a pre-S2 specific anti-hepatitis B virus mouse monoclonal antibody (H8 mAb) and synthetic peptides by competitive ELISA. The mAb showed preferences for long peptides with the sequence 120/12...
Antibody–antigen interactions are critical to our immune response, and understanding the structure-based biophysical determinants for their binding specificity and affinity is of fundamental importance. We present a computational structure-based cross-docking study to test the identification of native antibo...
The structure and antigen specificity of antibody binding sites can be influenced by clan-specific and family-specific amino acids in heavy chain frameworks 1 and 3. [Abst. 107]The structure and antigen specificity of antibody binding sites can be influenced by clan-specific and family-specific am...
Target specific antibody-superantigen conjugates and their preparation A soluble antibody conjugate comprising an antibody linked to a structure which is recognizable by T-cells and has the ability to direct T-cells to lyse the target cell, which is recognized by the antibody. The conjugate is ...
We formalized common immunological antibody-specificity prediction problems as ML tasks and confirmed that for both sequence- and structure-based tasks, accuracy-based rankings of ML methods trained on experimental data hold for ML methods trained on Absolut!-generated data. The Absolut! framework has...
Crystal Structure of the Anti-His Tag Antibody 3D5 Single-Chain Fragment (scFv) in Complex with a Oligohistidine peptide M Kaufmann,P Lindner,A Honegger,... 被引量: 0发表: 2002年 Targeted delivery of anti-CD19 liposomal doxorubicin in B-cell lymphoma: a comparison of whole monoclonal ...
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